Centre for Discovery Brain Sciences
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Dr Veronique Miron

The overall goal of our research is to understand the influences on central nervous system white matter in health, disease, and ageing, in order to identify effective treatments for neurological dysfunction.

Dr Veronique Miron

Senior Lecturer/MRC Senior Non-Clinical Fellow

  • Chancellor's Building
  • 49 Little France Crescent Edinburgh
  • EH16 4SB

Contact details

Personal profile

  • 2021-2026  MRC Senior Non-Clinical Fellow, Edinburgh UK DRI, The University of Edinburgh
  • 2015-2020  MRC Career Development Fellow, MRC CRH, The University of Edinburgh
  • 2014-2015  Biogen Independent Research Fellow, MRC CRH, The University of Edinburgh
  • 2010-2014  MS Society of Canada Postdoctoral Fellow, MRC SCRM, The University of Edinburgh

Research Theme

Research

We are investigating how microglia and other immune cells regulate central nervous system white matter health across the lifespan, in myelin development, homeostasis, disease and with ageing. We aim to identify novel therapeutic strategies for common neurological conditions such as cerebral palsy, multiple sclerosis and other neurodegenerative disorders, and cognitive decline with ageing.

Funding

Team members

  • Rebecca Holloway – (Senior research assistant)
  • Roya Esat – (MSc student in Integrated Neuroscience)
  • Lindsey Forbes- (Postdoctoral fellow)
  • Sarah Kent – (Wellcome Trust Translational Neuroscience PhD student)
  • Ayisha Mahmood – (NC3Rs PhD student)
  • Niamh McNamara – (Wellcome Trust Tissue Repair PhD student)
  • Irene Molina-Gonzalez – (Postdoctoral fellow)

Collaborations

Publications

1. Holloway RK, Ireland G, Sullivan G, Becher JC, Smith C, Boardman J, Gressens P, Miron VE (2021). Microglial inflammasome activation drives developmental white matter injury. Glia. Doi: 10.1002/glia.23963

2. Miron VE and Priller J. Investigating microglia in health and disease: challenges and opportunities (2020). Trends in Immunology. doi: 10.1016/j.it.2020.07.002

3. Lloyd A, Davies C, Holloway R, Labrak Y, Ireland G, Carradori D, Dillenburg A, Borger E, Soong D, Richardson J, Kuhlmann T, Williams A, Pollard J, des Rieux A, Priller J, Miron VE (2019). Central nervous system regeneration requires microglia death and repopulation. Nature Neuroscience. doi: 10.1038/s41593-019-0418-z

4. Lloyd AF, Miron VE. The regenerative role of microglia in the central nervous system (2019). Nature Reviews Neurology. doi: 10.1038/s41582-019-0184-2

5. Rojo R, Raper A, Ozdemir DO, Lefevre L, Grabert K, Wollscheid-Lengeling E, BradfordB, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham G, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C (2019). Deletion of CSF1R enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nature Communications. doi:10.1038/s41467-019-11053-8

6. Van Steenwinckel J, Schang AL, Krishnan ML, Degos V, Delahaye-Duriez A, Bokobza C, Csaba Z, Verdonk F, Montané A, Sigaut S, Hennebert O, Lebon S, Schwendimann L, Le Charpentier T, Hassan-Abdi R, Ball G, Aljabar P, Saxena A, Holloway RK, Birchmeier W, Baud O, Rowitch D, Miron VE, Chretien F, Leconte C, Besson VC, Petretto EG, Edwards AD, Hagberg H, Soussi-Yanicostas N, Fleiss B, Gressens P (2019) Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain. Brain. doi: 10.1093/brain/awz319.

7. Carradori D, Labrak Y, Miron VE, Saulnier P, Eyer J, Préat V, des Rieux A (2019) Retinoic acid-loaded NFL-lipid nanocapsules promote oligodendrogenesis in focal white matter lesion. Biomaterials. Doi: 10.1016/j.biomaterials.2019.119653

8. Dillenburg A, Ireland GI, Holloway RK, Davies CL, Evans FL, Swire M, Bechler ME, Soong D, Yuen TJ, Su GH, Becher JC, Smith C, Williams A, Miron VE (2018). Activin receptors regulate the oligodendrocyte lineage in health and disease. Acta Neuropathologica. ePub doi: 10.1007/s00401-018-1813-3.

9. Boardman JP, Ireland GI, Sullivan G, Pataky R, Fleiss B, Gressens P, Miron VE (2018) The cerebrospinal fluid inflammatory response to preterm birth. Frontiers in Physiology. doi: 10.3389/fphys.2018.01299.

10. Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, vWijngaarden AJ, Wajers AJ, Williams A, Franklin RJM, ffrench-Constant C (2013). M2 microglia/ macrophages drive oligodendrocyte differentiation during CNS remyelination. Nature Neuroscience. 16(9):1211-1218.

 

Information for students:

Willingness to discuss research projects with undergraduate and postgraduate students: YES - please click here