Centre for Discovery Brain Sciences
Centre for Discovery Brain Sciences Transparent Logo

Dr Thomas Becker

The group is interested in the regeneration of the spinal cord.

Dr Thomas Becker

Reader/Director MSc in Integrative Neuroscience

  • The Chancellor's Building
  • 49 Little France Crescent
  • EH16 4SB

Contact details

Personal profile

  • 2020 - Present Reader and Programme Director, MSc Integrative Neuroscience.
  • 2015 - 2020 Senior Lecturer and Programme Director, MSc Integrative     Neuroscience.
  • 2011 - 2015 Lecturer and Programme Director, MSc Integrative Neuroscience.
  • 2005 - 2011 Senior Researcher, Deanery of Biomedical Sciences, University of Edinburgh.
  • 2006 - Habilitation and Venia legendi, Medical faculty, University of Hamburg.
  • 2000 - 2005 Group Leader, Centre for Molecular Neurobiology Hamburg (ZMNH).
  • 1998 - 2000 Postdoc, Centre for Molecular Neurobiology Hamburg (ZMNH).
  • 1996 - 1998 Postdoc, Dept Dev Cell Biol, University of California, Irvine.
  • 1994 - 1996 Postdoc, Swiss Federal Institute of Technology, Zürich.
  • 1993  PhD Neurobiology, University of Bremen.
MScLogolowwithM

 

Thomas Becker is the director of the MSc by Research in Integrative Neurocience. 

Research Theme

Injury and Repair

Genes and Development

Research 

Zebrafish have an amazing capacity for central nervous system (CNS) regeneration. They regain function after complete lesions of the spinal cord. Such lesions in mammals are not repaired and functions are permanently lost.

Evidence suggests that ependymo-radial glial cells (ERGs) in the spinal cord are crucial for the regeneration process by generating new neurons and facilitating repair of axonal connections (for review see: Becker and Becker, 2015, Neuronal Regeneration from Ependymo-radial Glial Cells: Cook, Little Pot, Cook! Developmental Cell 32(4):516-27). Recent BBSRC funding allows us to ask two fundamental questions:

  • How can zebrafish replace lost neurons from adult stem cells?
  • What are the signals that promote neuronal regeneration?

To address these questions, we study gene regulation in ERGs that leads to reprogramming of quiescent ERGs for neurogenesis after a lesion, focussing on histone acetylation and we analyse immune signals as mediators of the regenerative response.

By analysing development and regeneration of important cell types in the zebrafish we hope to gain insight into fundamental developmental and regenerative mechanisms in the CNS, and to ultimately increase our understanding of human conditions, such as spinal cord injury. We closely collaborate with the group of Catherina Becker.

Group Members

Funding

  • BBSRC, BBSRC Eastbio, UoE Edinburgh/McGill Partnership

Collaborations

Selected Publications

* Senior author

Keatinge, M., Tsarouchas, T., Munir, T., Larraz, J., Gianni, D., Tsai, H.-H., Becker, C.G.*, Lyons, D.A.* & Becker, T.* Phenotypic screening using synthetic CRISPR gRNAs reveals pro-regenerative genes in spinal cord injury. BioRxiv  (2020).

Becker, T.* & Becker, C.G.* Dynamic cell interactions allow spinal cord regeneration in zebrafish. Curr Opin Physiol (2020).

Oprisoreanu, A.M., Smith, H.L., Arya, S., Webster, R., Zhong, Z., Wehner, D., Cardozo, M.J., Becker, T.*, Talbot, K.* & Becker, C.G.* Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation. Cell Rep 29, 1082-1098.e10 (2019).

Caldwell, L.J., Davies, N.O., Cavone, L., Mysiak, K.S., Semenova, S.A., Panula, P., Armstrong, J.D., Becker, C.G.* & Becker, T.* Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations. J Neurosci 39, 4694-4713 (2019).

Tsarouchas, T.M., Wehner, D., Cavone, L., Munir, T., Keatinge, M., Lambertus, M., Underhill, A., Barrett, T., Kassapis, E., Ogryzko, N., Feng, Y., van Ham, T.J., Becker, T.* & Becker, C.G.* Dynamic control of proinflammatory cytokines Il-1beta and Tnf-alpha by macrophages in zebrafish spinal cord regeneration. Nat Commun 9, 4670 (2018).

Becker, C.G. *, Becker, T.* & Hugnot, J.P.* The spinal ependymal zone as a source of endogenous repair cells across vertebrates. Prog Neurobiol 170, 67-80 (2018).

Wehner, D., Tsarouchas, T.M., Michael, A., Haase, C., Weidinger, G., Reimer, M.M., Becker, T.* & Becker, C.G.* Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish. Nat Commun 8, 126 (2017).

Drummond, N.J., Davies, N.O., Lovett, J.E., Miller, M.R., Cook, G., Becker, T., Becker, C.G., McPhail, D.B. & Kunath, T. A synthetic cell permeable antioxidant protects neurons against acute oxidative stress. Sci Rep 7, 11857 (2017).

Cardozo, M.J., Mysiak, K.S., Becker, T. & Becker, C.G*. Reduce, reuse, recycle - Developmental signals in spinal cord regeneration. Dev Biol 432, 53-62 (2017).

Boyd, P.J., Tu, W.Y., Shorrock, H.K., Groen, E.J.N., Carter, R.N., Powis, R.A., Thomson, S.R., Thomson, D., Graham, L.C., Motyl, A.A.L., Wishart, T.M., Highley, J.R., Morton, N.M., Becker, T., Becker, C.G., Heath, P.R. & Gillingwater, T.H. Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy. PLoS Genet 13, e1006744 (2017).

Ohnmacht, J., Yang, Y., Maurer, G.W., Barreiro-Iglesias, A., Tsarouchas, T.M., Wehner, D., Sieger, D., Becker, C.G.* & Becker, T.* Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish. Development 143, 1464-74 (2016).

Barreiro-Iglesias, A., Mysiak, K.S., Scott, A.L., Reimer, M.M., Yang, Y., Becker, C.G.* & Becker, T.* Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish. Cell Rep 13, 924-32 (2015).

Wishart, T.M., Mutsaers, C.A., Riessland, M., Reimer, M.M., Hunter, G., Hannam, M.L., Eaton, S., Fuller, H.R., Roche, S.L., Somers, E., Morse, R., Young, P.J., Lamont, D.J., Hammerschmidt, M., Joshi, A., Hohenstein, P., Morris, G.E., Parson, S.H., Skehel, P.A., Becker, T., Robinson, I.M., Becker, C.G., Wirth, B. & Gillingwater, T.H. Disrupted ubiquitin homeostasis and β-catenin signalling in spinal muscular atrophy. J Clinic Invest 124, 1821-34 (2014).

Sleigh, J.N., Barreiro-Iglesias, A., Oliver, P.L., Biba, A., Becker, T., Davies, K.E., Becker, C.G. & Talbot, K. Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy. Hum Mol Genet 23, 855-69 (2014).

Munzel, E., Becker, C.G., Becker, T.* & Williams*, A. Zebrafish regenerate full thickness optic nerve myelin after demyelination, but this fails with increasing age. Acta Neuropathol Commun 2, 77 (2014).

Becker, T.* & Becker, C.G.* Axonal regeneration in zebrafish. Curr Opin Neurobiol 27C, 186-191 (2014).

Reimer, M.M., Norris, A., Ohnmacht, J., Patani, R., Zhong, Z., Dias, T.B., Kuscha, V., Scott, A.L., Chen, Y.C., Rozov, S., Frazer, S.L., Wyatt, C., Higashijima, S., Patton, E.E., Panula, P., Chandran, S., Becker, T.* & Becker, C.G.* Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration. Dev Cell 25, 478-91 (2013).

Dias, T.B., Yang, Y.J., Ogai, K., Becker, T.* & Becker, C.G. Notch signaling controls generation of motor neurons in the lesioned spinal cord of adult zebrafish. J. Neurosci. 32, 3245-52 (2012).

Reimer, M.M., Sorensen, I., Kuscha, V., Frank, R.E., Liu, C., Becker, C.G. & Becker, T.* Motor neuron regeneration in adult zebrafish. J Neurosci 28, 8510-6 (2008).

Information for students:

Willingness to discuss research projects with undergraduate and postgraduate students: YES - please click here