Dr Leah Herrgen
We investigate the mechanisms underlying brain repair in the zebrafish.
- 2015 - Present Principal Investigator, CDBS, University of Edinburgh
- 2009 - 2015 Postdoc, University of Oxford
- 2008 - 2009 Postdoc, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
- 2004 - 2008 PhD, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
Our overarching goal is to elucidate the molecular and cellular mechanisms that enable or prevent central nervous system (CNS) repair, a fundamental unresolved challenge at the interface of neuroscience and tissue repair biology.
We are approaching this complex task by studying larvae of the zebrafish, a small tropical fish that is hardy and easy to maintain and breed. Importantly, larval zebrafish are almost entirely transparent, which means that we can easily watch cells and molecules in their nervous system in real time under a microscope.
Our current research focusses on the question of how cell death is regulated after CNS injury. We are using RNA sequencing and small molecule screening to identify genes and pathways that control how many nerve cells die after a CNS injury, with the aim of developing therapeutic strategies that can protect these cells.
Ultimately, understanding the cellular and molecular events that lead to successful nervous system repair in zebrafish may help us to develop novel therapeutic strategies for CNS injury in humans.
- François Waharte, Postdoctoral Fellow
- Chiara Herzog, Research Fellow
- David Greenald, Research Technician
- Prof. Catherina Becker, University of Edinburgh, UK
- Prof. David Lyons, University of Edinburgh, UK
- Dr Dirk Sieger, University of Edinburgh, UK
- Dr Veronique Miron, University of Edinburgh, UK
- Dr Martin Meyer, Kings College London, UK
- Dr Francesca Peri, EBML, Heidelberg, Germany
- Dr Barry McColl, The Roslin Institute, Edinburgh, UK
Herzog C, Pons Garcia L, Keatinge M, Greenald D, Moritz C, Peri F, Herrgen L. (2019) Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo. Development, 2019 May 10;146(9). pii: dev174698. doi: 10.1242/dev.174698.
- Herrgen L, Akerman CJ (2016). Mapping Neurogenesis Onset in the Optic Tectum of Xenopus Laevis.Developmental Neurobiology 76, 1328-1341.
- Herrgen L, Voss OP, Akerman CJ (2014). Calcium-dependent Neuroepithelial Contractions Expel Damaged Cells from the Developing Brain. Developmental Cell 31, 599-613. Featured in Science Perspectives. Calegari F (2014). Neurodevelopment. Tossed Out to Save the Masses. Science 346, 1298-1299.
Key Earlier Publications
- Herrgen L, Ares S, Morelli LG, Schröter C, Jülicher F, Oates AC (2010). Intercellular Coupling Regulates the Period of the Segmentation Clock. Current Biology 20, 1244-1253.
- Herrgen L, Schröter C, Bajard L, Oates AC (2009). Multiple Embryo Time-Lapse Imaging of Zebrafish Development. Methods in Molecular Biology 546, 243-254.
- Morelli LG, Ares S, Herrgen L, Schröter C, Jülicher F, Oates AC (2009). Delayed Coupling Theory of Vertebrate Segmentation. Human Frontier Science Program Journal 3, 55-66.
- Schröter C, Herrgen L, Cardona A, Brouhard GJ, Feldman B, Oates AC (2008). Dynamics of Zebrafish Somitogenesis. Developmental Dynamics 237, 545-553.