Centre for Discovery Brain Sciences
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Dr Henry J Olverman

We focus on human depressive disorders for which we can identify molecular mechanisms aimed at developing novel therapeutic strategies.

Henry J Olverman

Senior Lecturer

  • 1 George Square
  • Edinburgh, EH8 9JZ

Contact details

Personal profile

Lecturer, Senior Lecturer, University of Edinburgh

Research Assistant, Dept. of Pharmacology, University of Bristol

NATO Visiting Fellow,‘Mario Negri’ Institute of Pharmacology, Milan

Ph.D., University of Cambridge

Research Theme

Synapses, Circuits and Behaviour

Research

A key objective of the current research programme, conducted jointly with Paul Kelly, is to search for new molecular targets in human mood disorders using a genomic, neurobiological and systems approach in animal models. 

We focus on human depressive disorders for which we can identify molecular mechanisms aimed at developing novel therapeutic strategies.

We are currently testing the hypothesis that a history of exposure to MDMA in females may, by altering their stress responses during pregnancy, impinge upon the future physical and mental health of offspring.

In addition we are investigating the physiological, neurochemical, electrophysiological, endocrinological and behavioural effects in transgenic mice where the expression of SERT has been altered in order to further explore the involvement of the serotonergic system in the aetiology of clinical depression.

Funding

European Commission Research Directorates, Research & Technological Development Project, 6th Framework Programme

Selected Publications

JENNINGS, K.A., LODER, M.K., SHEWARD, J., PEI, Q., DEACON, R.M.J., BENSON, M.A., OLVERMAN, H.J., HASTIE, N.D., HARMAR, A.J., SHEN, S. and SHARP, T. (2006).  Increased expression of the 5-HT transporter confers a low anxiety phenotype linked to decreased 5-HT transmissionJ. Neurosci. 26, 8955 - 8964.

DAWSON, N., FERRINGTON, L., OLVERMAN, H.J. and KELLY, P.A.T. (2008).  Novel analysis for improved validity in semi-quantitative 2-deoxyglucose autoradiographic imaging.  J. Neurosci. Methods 175, 25 - 35.

DAWSON, N., FERRINGTON, L., OLVERMAN, H.J., HARMAR, A.J. and KELLY, P.A.T. (2009).  Gender influences the effect of a life-long increase in serotonin transporter function on cerebral metabolism.  J. Neurosci. Res. 87, 2375 - 2385.

 NEUFELD-COHEN, A., KELLY, P.A.T., PAUL, E.E., SKINNER, E., OLVERMAN, H.J., VAUGHAN, J.M., ISSLER, O., LOWRY, C.A., VALE, W.W., SECKL, J.R., CHEN. A. and JAMEISON, P.M. (2012).  Chronic activation of CRF type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and 5-HT responses to stressful challenge.  Biol. Psychiatry, 72, 437 - 447.

ISSLER, O., CARTER, R.N., PAUL, E.D., KELLY, P.A.T., OLVERMAN, H.J., LOWRY, C.A., SECKL, J.R., CHEN. A. and JAMIESON, P.M. (2014).  The role of the CRF receptor type 2 in stress recovery is mediated via modulation of serotonergic circuits in the lateral septum and subiculum.  Biology of Mood & Anxiety Disorders, 4, 1 - 10.