Centre for Discovery Brain Sciences
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Dr Alfredo Gonzalez-Sulser

We are working on developing new therapeutic strategies to treat epilepsy that rely on specifically modifying the activity of seizure-generating networks in the brain.

Alfredo Gonzalez-Sulser

Epilepsy Research United Kingdom Fellow

  • 1 George Square
  • Edinburgh, EH8 9JZ

Contact details

Personal profile

  • 2017 - Present: Epilepsy Research United Kingdom Fellow, Centre for Discovery Brain Research, University of Edinburgh.
  • 2014 - 2016: Marie Curie International Incoming Postdoctoral Fellow, Centre for Integrative Physiology, University of Edinburgh.
  • 2013 - 2016: Postdoctoral Research Fellow in the lab of Matt Nolan, Centre for Integrative Physiology, University of Edinburgh.
  • 2008 - 2012: PhD in Neuroscience in the labs of Rhonda Dzakpasu and Stefano Vicini, Interdisciplinary Program for Neuroscience, Georgetown University.
  • 2005 - 2007: Research Technician in the laboratory of Giovanni Cucchiaro, Children’s Hospital of Philadelphia.
  • 2001 - 2005: BAS in Biology, University of Pennsylvania.

Research Theme

Synapses/Circuits/Behaviour, Genes/Development                           

Research

Anti-epileptic drugs and surgery to remove epileptic tissue are often ineffective in controlling seizures in patients with temporal lobe epilepsy.

Furthermore, these treatments can have negative side effects as these interventions are not always specific to brain cells that start seizures, medications often affect the entire brain and surgical removal of epileptic tissue may damage neighbouring areas.

Therefore, new therapies are needed that will specifically block seizures while minimally affecting the rest of the brain.

We will identify populations of brain cells that could have powerful effects over the seizure generating network. We will use optogenetics to modulate the activity of these cells, to attempt to block seizures in a model of temporal lobe epilepsy by selectively controlling brain cells with light.

Strategies that manipulate the activity of these cells may be translated to the clinic, if they prove to be effective at blocking seizures.

Funding

Lab members

Collaborations

Recent publications

Brown, R, AD Lam, Gonzalez-Sulser A, A Ying, A Jones, M Chou, R Tzioras, M Jordan, C Jedrasiak-Cape, I Hemonnot, A Jaoude, MA Cole, A Cash, S Saito, T Saido, T Ribchester, R Hashemi K, Oren I. Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease. eNeuro. 5(2) e0426-17, 2018

Gonzalez-Sulser, A & Nolan, MF. Grid cells’ need for speed. Nat Neurosci. 20: 1–2, 2017.

Gonzalez-Sulser A, Parthier D, Candela A, McClure C, Pastoll H, Garden D, Nolan, MF. GABAergic Projections from the Medial Septum Selectively Inhibit Interneurons in the Medial Entorhinal Cortex. J Neurosci, 34(50): 16739-16743, 2014.

Gonzalez-Sulser A, Wang J, Queenan BQ, Avoli M, Vicini S, Dzakpasu R. Multi-Electrode Array Recordings of Hippocampal Neuron Firing and Slow Field Potentials in the in vitro 4-aminopyridine Epilepsy Model. J Neurophysiol (9): 2568-580, 2012.

Motamedi GK, Gonzalez-Sulser A, Dzakpasu R, Vicini S. Cellular Mechanisms of Desynchronizing Effects of Hypothermia in an In Vitro Epilepsy Model. Neurotherapeutics. (1): 199-209, 2012.

Gonzalez-Sulser A, Wang J, Motamedi GK, Avoli M, Vicini S, Dzakpasu R, The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. Neuropharmacology. (60): 1142-1153, 2011.

Cucchiaro G, Xiao Y, Gonzalez-Sulser A, Kellar KJ. Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug. Anesthesiology. 109 (3):512-9. 2008.

Ganesh A, Gonzalez-Sulser A, Chaijale N, Cucchiaro G. Electrophysiologic effects of systemic and locally infused epibatidine on locus coeruleus neurons. Eur J Pharmacol. 14; 584 (1):93-9, 2008.

Park MY, Wu G, Gonzalez-Sulser A, Vaucheret H, Poethig RS.Nuclear processing and export of microRNAs in Arabidopsis. Proc Natl Acad Sci. 8; 102(10):3691-6, 2005