Centre for Discovery Brain Sciences
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Zahid Padamsey

Understanding information processing in the cortex in vivo.

Dr Zahid Padamsey

Postdoctoral Research Fellow

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh, EH8 9XD

Contact details

Personal profile

  • BSc Hons in Neuroscience - Toronto, 2005-09
  • MSc Neuroscience - Oxford, 2009-10.
  • -DPhil Neuroscience - Oxford, 2010-14.
  • Junior Research Fellow - Magdalen college, Oxford, 2014-17.
  • 1851 Research Fellow - 2017-2020.


My previous work sought to characterize novel rules and mechanisms of synaptic plasticity at  hippocampal synapses in vitro. My current interest is in understanding information processing in the cortex in vivo. In particular, I am using two photon Ca2+ imaging in the primary visual cortex of awake rodents to investigate how visual processing is shaped by synaptic activity and behavioural need.units in sensory perception. 

Speed or precision? Dynamics of information flow in the brain

Recent publications

  • Padamsey, Z*., Tong, R., & Emptage, N*. (2017). Glutamate is required for depression but not potentiation of long-term presynaptic function. Elife, 6, e29688. doi: 10.7554/eLife.29688 *co-corresponding author.
  • Jeans, A. F., van Heusden, F. C., Al-Mubarak, B., Padamsey, Z., & Emptage, N. J. (2017). Homeostatic Presynaptic Plasticity Is Specifically Regulated by P/Q-type Ca(2+) Channels at Mammalian Hippocampal Synapses. Cell Rep, 21(2), 341-350. doi: 10.1016/j.celrep.2017.09.061Costa, R. P., Padamsey, Z., D'Amour, J. A., Emptage, N. J., Froemke, R. C., & Vogels, T. P. (2017). Synaptic Transmission Optimization Predicts Expression Loci of Long-Term Plasticity. Neuron, 96(1), 177-189.e177. doi: 10.1016/j.celrep.2017.09.061
    1. 10.1016/j.neuron.2017.09.021.
  • Padamsey, Z., McGuinness, L., & Emptage, N. J. (2017). Inhibition of lysosomal Ca(2+) signalling disrupts dendritic spine structure and impairs wound healing in neurons. Commun Integr Biol, 10(5-6), e1344802. doi: 10.1080/19420889.2017.1344802.
  • Padamsey, Z., McGuinness, L., Bardo, S. J., Reinhart, M., Tong, R., Hedegaard, A., Hart, M.L., Emptage, N. J. (2017). Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines. Neuron, 93(1), 132-146. doi: 10.1016/j.neuron.2016.11.013.
  • Padamsey, Z., & Emptage, N. (2014). Two sides to long-term potentiation: a view towards reconciliation. Philos Trans R Soc Lond B Biol Sci, 369(1633), 20130154. doi: 10.1098/rstb.2013.0154
  • Padamsey, Z., & Jeans, A. (2012). Imaging synaptic vesicles using VGLUT1-venus knock-in mice: insights into the dynamic nature of intersynaptic vesicle exchange. J Neurosci, 32(10), 3284-3286. doi: 10.1523/JNEUROSCI.6425-11.2012.
  • Jeans, A., Malins, R., Padamsey, Z., Reinhart, M., & Emptage, N. (2011). Increased expression of dysbindin-1A leads to a selective deficit in NMDA receptor signaling in the hippocampus. Neuropharmacology, 61(8), 1345-1353. doi: 10.1016/j.neuropharm.2011.08.007.
  • Padamsey, Z., & Emptage, N. J. (2011). Imaging synaptic plasticity. Mol Brain, 4, 36. doi: 10.1186/1756-6606-4-36.
  • Jeans A., Malins R., Padamsey Z., Reinhart M., Emptage N.J., 2011, Increased expression of dysbindin-1a leads to a selective deficit in NMDA receptor signalling in the hippocampus, Neuropharmacology, 61, 1345-1353.