Centre for Discovery Brain Sciences
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Sybille Köhler

The study of mechanosensation and cell polarity signalling pathways in Drosophila nephrocytes.

Dr Sybille Köhler

Postdoctural Researcher

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh EH8 9XD

Contact details

Personal profile

  • 2019 - Present: PostDoc - Centre for Discovery Brain Sciences, Biomedical Sciences, University of Edinburgh (lab of Barry Denholm), Scotland, UK.
  • 2016 - 2019: PostDoc - Department II of Internal Medicine and Center for Molecular Medicine, (lab of Prof. P. Brinkkötter), Cologne,Germany.
  • 2017 - 2017:  Research stay - (in the lab of Barry Denholm),  University of Edinburgh, Scotland.
  • 2011 - 2016PhD student - Department II of Internal Medicine, Nephrolab (lab of Prof. T. Benzing), Cologne,Germany.

Research

In the lab of Barry Denholm I will study mechanosensation and cell polarity signalling pathways in Drosophila nephrocytes. I aim to setup novel in vivo imaging approaches to visualizes mechanotransduction processes and their downstream events in nephrocytes.

Relevant publications

2019

  • Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB. Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics.  Cell Rep. 2019 Apr 30;27(5):1551-1566.e5. doi: 10.1016/j.celrep.2019.04.012.

2018

  • Schroeter CB, Koehler S, Kann M, Schermer B, Benzing T, Brinkkoetter PT,  Rinschen MM.  Protein half-life determines expression of proteostatic networks in podocyte differentiation.  FASEB J. 2018 Sep;32(9):4696-4713.

2017

  • Koehler S*, Brähler S*, Braun F, Hagmann H, Rinschen MM, Späth MR, Höhne M, Wunderlich FT, Schermer B, Benzing T, Brinkkoetter PT.  A T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes.   Kidney Int. 2017 Feb 7. pii: S0085-2538(16)30745-1.

2016

  • Koehler S*, Brähler S*, Binz J, Hackl M, Hagmann H, Kuczkowski A, Vogt M, Wunderlich C, Wunderlich T, Schweda F, Schermer B, Benzing T, Brinkkoetter PT.  A Single and Transient Ca2+ Wave in Podocytes does not induce Changes in Glomerular Filtration and Perfusion.   Sci Rep. 2016 Oct 19;6:35400.
  • Rinschen MM, Schroeter CB, Koehler S, Ising C, Schermer B, Kann M, Benzing T, Brinkkoetter PT.   Quantitative deep-mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation.   Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C404-17.
  • Koehler S, Tellkamp F, Niessen C, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT.  Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.  Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F112-9.
  • Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT. Prohibitin-2 depletion unravels extra-mitochondrial functions at the kidney filtration barrier.   Am J Pathol. 2016 May;186(5):1128-39.

2015

  • Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT. Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.   EMBO Mol Med. 2015 Feb 2;7(3):275-87.