Centre for Discovery Brain Sciences
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Sally Till

The overarching goal of my current work is to aid in improving therapeutic approaches to cognitive disorders with the ultimate aim of enhancing human clinical trial efficacy.

Dr Sally Till

Walter Muir Autistica Fellow

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh EH8 9XD

Contact details

Personal profile

  • 2012–present: Autistica Fellow at the Patrick Wild Centre, University of Edinburgh.
  • 2006–2012: Postdoctoral researcher, Centre for Integrative Physiology, University of Edinburgh.
  • 2006: Ph.D. in Neurobiology and Behaviour at Columbia University, New York, USA.
  • 1995: B.Sc. in Neuroscience and Physiology at the University of California, San Diego, USA.

Research

While preclinical models have provided a background for understanding the mechanisms underlying disease pathogenesis, clinical trials are essential because the predictive utility of animal studies for therapeutic strategies in humans remains controversial; this stems, in part, from the fact that each model organism has its own strengths and weaknesses.

One focus of my current work is to develop an improved experimental framework for studying cognitive and behavioural symptoms of autism spectrum disorders and related disorders.

This experimental framework takes advantage of the unique anatomical, physiological and behavioural characteristics afforded by using rats as a model organism to answer questions that were previously intractable in disease models based in other species.

Funding

Collaborations

Publications

Till, S.M., Asiminas, A., Jackson, A.D., Katsanevaki, D., Barnes, S.A., Osterweil, E.K., Bear, M.F., Chattarji, S., Wood, E., Wyllie, D.J.A., and Kind, P.C. (2015) Conserved hippocampal cellular pathophysiology but distinct behavioral deficits in a new rat model of FXS. Hum Molec Genet. Hum Molec Genet. pii: ddv299.

Till, S.M., Wijetunge, L.S., Seidel, V.G., Harlow, E.G., Wright, A.K., Bagni, C., Contractor, A., Gillingwater T.H., Kind P.C. (2012) Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome. Hum Molec Genet. 21(10):2143-56.

Till, S.M., Li, H-L., Miniaci, M.C., Kandel, E.R. Choi, Y-B. (2011) A pre-synaptic role of FMRP in protein synthesis-dependent long-term plasticity in Aplysia Californica. Learn & Mem. 18(1):39-48.

Till, S.M. The developmental roles of FMRP. (2010) Biochem Soc Trans. 38(2):507-10.

Harlow, E.G., Till, S.M., Russell, T.A, Wijetunge, L.S., Kind, P.C., Contractor, A. (2010) Critical period plasticity is disrupted in the barrel cortex of fragile X mice. Neuron. 65(3):385-98.

Wijetunge, L.S., Till S.M., Gillingwater T.H., Ingham C.A., Kind P.C. (2008) mGluR5 regulates glutamate-dependent development of the mouse somatosensory cortex. J Neurosci. 28(49):13028-37.