I am part of the Zebrafish Inflammation and Neurodegeneration Group (ZING). Contact type Person First name Marcus Surname Keatinge Title Dr Role Postdoctoral Research Fellow Organisation 1 Chancellor's Building Organisation 2 49 Little France Crescent Organisation 3 Edinburgh, EH16 4SB Work phone +44 (0)131 242 9411 Email Mkeatin2@ed.ac.uk Personal profile 2015-2017 Parkinson’s UK Post-Doc at the University of Sheffield in the group of Prof Oliver Bandmann. 2010-2015 BBSRC CASE PhD studentship with Eli Lilly at the University of Sheffield, in the group of Prof Oliver Bandmann. 2009-2010 Industrial Intern at Pfizer UK. Structural biology and biophysics group. 2006-2009 MBiolSci in Molecular Biology at the University of Sheffield. Molecular Biology and Biotechnology department. Research I am part of the Zebrafish Inflammation and Neurodegeneration Group (ZING). We are developing new transgenic lines and Crispr/Cas9 based tools in Zebrafish, to further understand inflammation in the context of neurodegeneration and neuronal injury. Recent publications SOMAN, S., KEATINGE, M., MOEIN, M., DACOSTA, M., MORTIBOYS, H., SKUPIN, A., SUGUNA, S., BAZALA, M., KUZNICKI, J., BANDMANN, O., Academic Paper. Inhibition of themitochondrial calcium uniporter (MCU) rescues dopaminergic neurons in pink1-/- zebrafish. (2015). Eur J Neurosci, 13473, 1-8. KEATINGE, M., BUI, H., MENKE, A., CHEN, Y. C., SOKOL, A. M., BAI, Q., ELLETT, F., DA COSTA, M., BURKE, D., GEGG, M., TROLLOPE, L., PAYNE, T., MCTIGHE, A., MORTIBOYS, H., DE JAGER, S., NUTHALL, H., KUO, M. S., FLEMING, A., SCHAPIRA, A. H., RENSHAW, S. A., HIGHLEY, J. R., CHACINSKA, A., PANULA, P., BURTON, E. A., O'NEILL, M. J. & BANDMANN, O. Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha- synuclein-independent neuronal cell death. (2015). Hum Mol Genet, 24, 6640-52 BAKER, D. J., BLACKBURN, D. J., KEATINGE, M., SOKHI, D., VISKAITIS, P., HEATH, P.R., FERRAIUOLO, L., KIRBY, J. & SHAW, P. J. Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis. (2015). Front Cell Neurosci, 9, 410. KEATINGE, M*., FLINN, L. J*., BRETAUD, S., MORTIBOYS, H., MATSUI, H., DE FELICE, E., WOODROOF, H. I., BROWN, L., MCTIGHE, A., SOELLNER, R., ALLEN, C. E., HEATH, P. R., MILO, M., MUQIT, M. M., REICHERT, A. S., KÖSTER, R. W., INGHAM, P. W. & BANDMANN, O. TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency. (2013). Ann Neurol, 74, 837-47. *Equal Contribution This article was published on 2022-10-17
Contact type Person First name Marcus Surname Keatinge Title Dr Role Postdoctoral Research Fellow Organisation 1 Chancellor's Building Organisation 2 49 Little France Crescent Organisation 3 Edinburgh, EH16 4SB Work phone +44 (0)131 242 9411 Email Mkeatin2@ed.ac.uk