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Marcus Keatinge

I am part of the Zebrafish Inflammation and Neurodegeneration Group (ZING).

Dr Marcus Keatinge

Postdoctoral Research Fellow - Becker Group

  • Chancellor's Building
  • 49 Little France Crescent
  • Edinburgh, EH16 4SB

Contact details

Personal profile

  • 2015-2017 Parkinson’s UK Post-Doc at the University of Sheffield in the group of Prof Oliver Bandmann.
  • 2010-2015 BBSRC CASE PhD studentship with Eli Lilly at the University of Sheffield, in the group of Prof Oliver Bandmann.
  • 2009-2010 Industrial Intern at Pfizer UK. Structural biology and biophysics group.
  • 2006-2009 MBiolSci in Molecular Biology at the University of Sheffield. Molecular Biology and Biotechnology department.

Research

I am part of the Zebrafish Inflammation and Neurodegeneration Group (ZING). We are developing new transgenic lines and Crispr/Cas9 based tools in Zebrafish, to further understand inflammation in the context of neurodegeneration and neuronal injury.

  

Recent publications

  • SOMAN, S., KEATINGE, M., MOEIN, M., DACOSTA, M., MORTIBOYS, H., SKUPIN, A., SUGUNA, S., BAZALA, M., KUZNICKI, J., BANDMANN, O., Academic Paper. Inhibition of themitochondrial calcium uniporter (MCU) rescues dopaminergic neurons in pink1-/- zebrafish. (2015). Eur J Neurosci, 13473, 1-8.
  • KEATINGE, M., BUI, H., MENKE, A., CHEN, Y. C., SOKOL, A. M., BAI, Q., ELLETT, F., DA COSTA, M., BURKE, D., GEGG, M., TROLLOPE, L., PAYNE, T., MCTIGHE, A., MORTIBOYS, H., DE JAGER, S., NUTHALL, H., KUO, M. S., FLEMING, A., SCHAPIRA, A. H., RENSHAW, S. A., HIGHLEY, J. R., CHACINSKA, A., PANULA, P., BURTON, E. A., O'NEILL, M. J. & BANDMANN, O. Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha- synuclein-independent neuronal cell death. (2015). Hum Mol Genet, 24, 6640-52 
  • BAKER, D. J., BLACKBURN, D. J., KEATINGE, M., SOKHI, D., VISKAITIS, P., HEATH, P.R., FERRAIUOLO, L., KIRBY, J. & SHAW, P. J. Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis. (2015). Front Cell Neurosci, 9, 410.
  • KEATINGE, M*., FLINN, L. J*., BRETAUD, S., MORTIBOYS, H., MATSUI, H., DE FELICE, E., WOODROOF, H. I., BROWN, L., MCTIGHE, A., SOELLNER, R., ALLEN, C. E., HEATH, P. R., MILO, M., MUQIT, M. M., REICHERT, A. S., KÖSTER, R. W., INGHAM, P. W. & BANDMANN, O. TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency. (2013). Ann Neurol, 74, 837-47.

*Equal Contribution