Centre for Discovery Brain Sciences
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Katharine Dobson

The physiological role of ADBE in the well-established circuits of the hippocampus.

Dr Katharine L Dobson

Postdoctoral Research Fellow

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh EH8 9XD

Contact details

Personal profile

  • 2017- Present:    Postdoctoral Research Fellow in Neuroscience - Centre for Discovery Brain Sciences, University of Edinburgh.                      
  • 2016-2017:           Postdoctoral Research Associate in Neuroscience - Department of Neuroscience, Psychology & Behaviour; University of Leicester.
  • 2013-2016:           Research Fellow in Neuropharmacology - School of Life Sciences, Queen’s Medical Centre, University of Nottingham.
  • 2012-2013:           Research Assistant - School of Biosciences, Sutton Bonington Campus, University of Nottingham.
  • 2008-2012:           PhD in Neurophysiology - School of Biosciences, Sutton Bonington Campus, University of Nottingham.

Research

Maintenance of neuronal transmission is dependent on endocytosis of synaptic vesicles – of which activity-dependent bulk endocytosis (ADBE) is the dominant mode in neurons during periods of intense activity.

My current research examines the physiological role of ADBE in the well-established circuits of the hippocampus and seeks to determine its impact on neurotransmission at the synaptic and neuronal level. I am also highly motivated to explore the diverse applications of electrophysiological techniques in other research areas, particularly with a view to enhancing our understanding of complex neurological conditions such as neurodegenerative diseases.

Recent publications

Ivanova D, Dobson KL, Gajbhiye A, Davenport EC, Hacker D, Ultanir SK, Trost M, Cousin MA. (2021) - Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes. Science Advances. doi:10.1126/sciadv.abf3873

Dobson KL, Howe CL, Nishimura Y, Marra V. (2019) - Dedicated setup for the photoconversion of fluorescent dyes for functional electron microscopy. Front Cell Neurosci. doi:10.3389/fncel.2019.00312

Dobson KL, Smith ZH, Bellamy TC. (2018) - Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission. PLoS ONE. doi.org/10.1371/journal.pone.0200937

Croft WC, Dobson KL, Bellamy TC. (2015) - Plasticity of neuron-glial transmission: equipping glia for long term integration of network activity. Neural Plasticity. doi:10.1155/2015/765792.

Dobson KL, Jackson C, Balakrishnan S, Bellamy TC. (2015) - Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling. PLoS ONE. doi: 10.1371/journal.pone.0125974.

Kelly S, Dobson KL, Harris J. (2013) - Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat. Osteoarthritis & Cartilage, 21, 1327-35.

Dobson KL and Harris J. (2012) - A detailed surgical method for mechanical decerebration of the rat. Experimental Physiology, 97, 693-8.