Centre for Discovery Brain Sciences
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Katharine Dobson

The physiological role of ADBE in the well-established circuits of the hippocampus.

Dr Katharine L Dobson

Postdoctoral Research Fellow

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh EH8 9XD

Contact details

Personal profile

  • 2017- Present:    Postdoctoral Research Fellow in Neuroscience - Centre for Discovery Brain Sciences, University of Edinburgh.                      
  • 2016-2017:           Postdoctoral Research Associate in Neuroscience - Department of Neuroscience, Psychology & Behaviour; University of Leicester.
  • 2013-2016:           Research Fellow in Neuropharmacology - School of Life Sciences, Queen’s Medical Centre, University of Nottingham.
  • 2012-2013:           Research Assistant - School of Biosciences, Sutton Bonington Campus, University of Nottingham.
  • 2008-2012:           PhD in Neurophysiology - School of Biosciences, Sutton Bonington Campus, University of Nottingham.

Research

Maintenance of neuronal transmission is dependent on endocytosis of synaptic vesicles – of which activity-dependent bulk endocytosis (ADBE) is the dominant mode in neurons during periods of intense activity.

My current research examines the physiological role of ADBE in the well-established circuits of the hippocampus and seeks to determine its impact on neurotransmission at the synaptic and neuronal level. I am also highly motivated to explore the diverse applications of electrophysiological techniques in other research areas, particularly with a view to enhancing our understanding of complex neurological conditions such as neurodegenerative diseases.

Recent publications

Dobson KL and Bellamy TC. (2015) -Localization of presynaptic plasticity mechanisms enables functional independence of synaptic and ectopic transmission in the cerebellum. Neural Plasticity. doi:10.1155/2015/602356.

Croft WC, Dobson KL, Bellamy TC. (2015) - Plasticity of neuron-glial transmission: equipping glia for long term integration of network activity. Neural Plasticity. doi:10.1155/2015/765792.

Dobson KL, Jackson C, Balakrishnan S, Bellamy TC. (2015) - Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling. PLoS ONE.  doi: 10.1371/journal.pone.0125974.

Balakrishnan S, Dobson KL, Jackson C, Bellamy TC. (2014) - Ectopic release of glutamate contributes to spillover at parallel fibre synapses in the cerebellum. J Physiol 592, 1493-503.

Kelly S, Dobson KL, Harris J. (2013) - Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat. Osteoarthritis & Cartilage, 21, 1327-35.

Dobson KL and Harris J. (2012) - A detailed surgical method for mechanical decerebration of the rat. Experimental Physiology, 97, 693-8.