Dr Jamie Marland
Communication between neurons in the brain occurs at synapses, where information is relayed by the release of chemical neurotransmitters from synaptic vesicles.
- 2012 - present: Postdoctoral Research Fellow in the Prof M. Cousin lab, Centre for Integrative Physiology, University of Edinburgh
- 2007 - 2011: PhD in Clinical Neurosciences at the Dr P. Buttery lab, Centre for Brain Repair, University of Cambridge
- 2006 - 2007: Research Assistant, Centre for Brain Repair, University of Cambridge
- 2002 – 2005: BA (Hons) in Natural Sciences, University of Cambridge
- 2001 – 2002: Technician in the Prof A. Smith lab with Prof I. Chambers, Institute for Stem Cell Research, University of Edinburgh
Local signalling pathways exist within the synaptic terminal to sense the intensity of the transmitted signal, and then activate appropriate vesicle and membrane recycling pathways to restore and maintain the terminal following its activity.
These processes allow the terminal to continue performing normally, and I am investigating whether accurate control over their action is lost under neurological disease conditions, using a preclinical model of intellectual disability and neurodegeneration.
Through this work we hope to gain a better understanding of how neuronal function may be impaired in disease, and to identify new targets for future therapies.
- Medical Research Council
- Marland JR, Pan D, Buttery PC. (2011) Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons. J Biol Chem. 286(1):199-207
- Robertson M, Stenhouse F, Colby D, Marland JR, Nichols J, Tweedie S, Chambers I. (2006) Nanog retrotransposed genes with functionally conserved open reading frames. Mamm Genome. 17(7):732-43