Centre for Discovery Brain Sciences
Centre for Discovery Brain Sciences Transparent Logo

James Catterson

Mechanisms of synapse degeneration in Alzheimer’s disease.

Dr James Catterson

Research Fellow

  • 1 George Square
  • Edinburgh, EH8 9JZ

Contact details

Personal profile

  • 2019 - present: Research Fellow, University of Edinburgh.
  • 2013 - 2019: Research Fellow, University College London.
  • 2009 - 2013: Ph.D. Cardiovascular Biology, University of Edinburgh.
  • 2008 - 2009: MSc, Cardiovascular Biology, University of Edinburgh.
  • 2004 - 2008: BSc, Neuroscience, University of Edinburgh.


Abeta Eyes

My research focuses on the mechanisms of synapse degeneration in Alzheimer’s disease. I use the power and speed of Drosophila genetics coupled with Array Tomography (AT), a sophisticated imaging technique, to examine why Alzheimer's proteins, such as Tau and Aβ, are so toxic to neurons.


  • Catterson JH, Khericha M, Dyson MC, Vincent AJ, Callard R, Haveron SM, Rajasingam A, Ahmad M, Partridge L. Short-term, Intermittent Fasting induces long-lasting Gut Health and TOR-independent Lifespan Extension. Current Biology. 2018 Jun 4;28(11):1714-1724.
  • Ivy JR, Drechsler M, Catterson JH, Bodmer R, Ocorr K, Paululat A, Hartley PS. Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. PLoS One. 2015 Aug 24;10(8):e0134620.
  • Catterson JH, Heck MM, Hartley PS. Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogaster. PLoS One. 2013 May 15;8(5):e62958.
  • Tracey CJ, Pan X, Catterson JH, Harmar AJ, Ahmood Hussain M, Hartley PS. Diurnal expression of Thrombopoietin is regulated by Clock. Journal of Thrombosis and Haemostasis. 2012 Apr;10(4):662-9.
  • Dear JW, Simpson KJ, Nicolai MP, Catterson JH, Street J, Huizinga T, Craig DG, Dhaliwal K, Webb S, Bateman DN, Webb DJ. Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen induced liver injury. Journal of Immunology. 2011 Sep 15;187(6):3347-52.
  • Catterson JH, Knowles-Barley S, James K, Heck MMS, Harmar AJ, Hartley PS. Dietary modulation of Drosophila sleep-wake behaviour. PLoS One. 2010 Aug 10;5(8):e12062.
  • Dear JW, Nicolai MPJ, Catterson JH, Huizinga T, Dhaliwal K, Bateman DN, Waring WS, Webb DJ, Simpson K. Cyclophilin A is a Key mediator of Paracetamol Poisoning. Clinical Toxicology. 2010 Mar 1;48(3):266-267.