Centre for Discovery Brain Sciences
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Ines S Amorim

Synaptic function in health and disease.

Dr Ines S Amorim

Postdoctoral Researcher

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh EH8 9XD

Contact details

Personal profile

  • 2016 - Present: Postdoctoral researcher in the lab of Dr. Christos Gkogkas. University of Edinburgh, UK.
  • 2012 - 2016: PhD in Neuroscience in the lab of Prof Thomas Gillingwater. University of Edinburgh, UK.
  • 2011 - 2012: MScR Biomedical Sciences. University of Edinburgh, UK.
  • 2008 - 2011: BSc Biomedical Engineering. Instituto Superior Tecnico, University of Lisbon, Portugal.

Research

My research focuses on the molecular mechanisms governing synaptic function in health and disease. In particular, I am interested in the contribution of translational regulation to neuronal function and in the context of neurodevelopmental disorders, such as Autism Spectrum Disorders (ASD), Fragile X Syndrome (FXS) and Intellectual Disabilities (ID).

Relevant publications

Uttam, S., Wong, C., Amorim, I.S., Jafarnejad, S.M., Tansley, S.N., Yang, J., Prager-Khoutorsky, M., Mogil, J.S., Gkogkas, C.G., and Khoutorsky, A. (2018). Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiology of Pain. In press

Amorim, I.S., Kedia, S., Kouloulia, S., Simbriger, K., Gantois, I., Jafarnejad, S.M., Li, Y., Kampaite, A., Pooters, T., Romano, N., and Gkogkas, C.G. (2018). Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation. Journal of Neuroscience 38, 2118-2133. 

Amorim, I.S., Graham, L.C., Carter, R.N., Morton, N.M., Hammachi, F., Kunath, T., Pennetta, G., Carpanini, S.M., Manson, J.C., Lamont, D.J., Wishart, T.M., and Gillingwater, T.H. (2017). Sideroflexin 3 is an alpha-synuclein-dependent mitochondrial protein that regulates synaptic morphology. Journal of Cell Science 130, 325-331. 

Amorim, I.S., Mitchell, N.L., Palmer, D.N., Sawiak, S.J., Mason, R., Wishart, T.M., and Gillingwater, T.H. (2015). Molecular neuropathology of the synapse in sheep with CLN5 Batten disease. Brain and Behavior 5, e00401.