Synaptic function in health and disease. Contact type Person First name Ines Surname Amorim Additional name S Title Dr Role Postdoctoral Researcher Organisation 1 Hugh Robson Building Organisation 2 15 George Square Organisation 3 Edinburgh EH8 9XD Work phone +44 (0) 131 651 1695 Email i.amorim@ed.ac.uk Personal profile 2016 - Present: Postdoctoral researcher in the lab of Dr. Christos Gkogkas. University of Edinburgh, UK. 2012 - 2016: PhD in Neuroscience in the lab of Prof Thomas Gillingwater. University of Edinburgh, UK. 2011 - 2012: MScR Biomedical Sciences. University of Edinburgh, UK. 2008 - 2011: BSc Biomedical Engineering. Instituto Superior Tecnico, University of Lisbon, Portugal. Research My research focuses on the molecular mechanisms governing synaptic function in health and disease. In particular, I am interested in the contribution of translational regulation to neuronal function and in the context of neurodevelopmental disorders, such as Autism Spectrum Disorders (ASD), Fragile X Syndrome (FXS) and Intellectual Disabilities (ID). Relevant publications Uttam, S., Wong, C., Amorim, I.S., Jafarnejad, S.M., Tansley, S.N., Yang, J., Prager-Khoutorsky, M., Mogil, J.S., Gkogkas, C.G., and Khoutorsky, A. (2018). Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiology of Pain. In press Amorim, I.S., Kedia, S., Kouloulia, S., Simbriger, K., Gantois, I., Jafarnejad, S.M., Li, Y., Kampaite, A., Pooters, T., Romano, N., and Gkogkas, C.G. (2018). Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation. Journal of Neuroscience 38, 2118-2133. Amorim, I.S., Graham, L.C., Carter, R.N., Morton, N.M., Hammachi, F., Kunath, T., Pennetta, G., Carpanini, S.M., Manson, J.C., Lamont, D.J., Wishart, T.M., and Gillingwater, T.H. (2017). Sideroflexin 3 is an alpha-synuclein-dependent mitochondrial protein that regulates synaptic morphology. Journal of Cell Science 130, 325-331. Amorim, I.S., Mitchell, N.L., Palmer, D.N., Sawiak, S.J., Mason, R., Wishart, T.M., and Gillingwater, T.H. (2015). Molecular neuropathology of the synapse in sheep with CLN5 Batten disease. Brain and Behavior 5, e00401. This article was published on 2022-10-17
Contact type Person First name Ines Surname Amorim Additional name S Title Dr Role Postdoctoral Researcher Organisation 1 Hugh Robson Building Organisation 2 15 George Square Organisation 3 Edinburgh EH8 9XD Work phone +44 (0) 131 651 1695 Email i.amorim@ed.ac.uk