Gilliard Lach

Personal profile

• 2016-2017: Senior Postdoctoral researcher, APC Microbiome Institute, University College Cork, Cork, Ireland.
• 2013-2015: Postdoctoral researcher, Institute of Pharmacology, Medical University Innsbruck, Innsbruck, Austria.
• 2009-2013: PhD in Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil.

Research

My research focuses in identifying the molecules, cells and circuits underlying social behaviour in rodent models of Autism, Intellectual disability and Depression.

Recent publications

Lach, G.; Schellekens, H.; Dinan, T.G.; Cryan, J.F. Anxiety, Depression, and the Microbiome: A Role for Gut Peptides. Neurotherapeutics (2018), 15(1):36-59. doi: 10.1007/s13311-017-0585-0.

Wood, J.; Verma, D.; Lach, G.; Bonaventure, P.; Herzog, H.; Sperk, G.; Tasan, R. Structure and function of the amygdaloid NPY system: NPY Y2 receptors regulate excitatory and inhibitory synaptic transmission in the centromedial amygdala. Brain Struct Funct (2016), 221(7):3373-91. doi: 10.1007/s00429-015-1107-7.

Hoeller, A.A.; Costa, A.P.R.; Bicca, M.A.; Matheus, F.C.; Lach. G.; Spiga, F.; Lightman, S.L.; Walz, R.; Collingridge, G.L.; Bortolotto, Z.A.; de Lima, T.C.M. The role of hippocampal NMDA receptors in long-term emotional responses following muscarinic receptor activation. PLoS ONE (2016), 11(1): e0147293. doi:10.1371/journal.pone.0147293.

Lach, G.; Bicca, M.A.; Hoeller, A.A.; da Silva Santos, E.C.; Costa, A.P.; de Lima, T.C. Short-term enriched environment exposure facilitates fear extinction in adult rats: The NPY-Y1 receptor modulation. Neuropeptides (2016), 55:73-8.  doi: 10.1016/j.npep.2015.10.001. 

Tasan, R.O.; Verma, D.; Wood, J.; Lach, G.; Hörmer, B.; de Lima, T.C.; Herzog, H.; Sperk, G. The role of Neuropeptide Y in fear conditioning and extinction. Neuropeptides (2016), 55:111-26. doi: 10.1016/j.npep.2015.09.007.

Verma, D.; Wood, J.; Lach, G.; Herzog, H.; Sperk, G.; Tasan, R. Hunger promotes fear extinction by activation of an amygdala microcircuit. Neuropsychopharmacology (2016), 41(2): 431-9, doi: 10.1038/npp.2015.163.

Verma, D.; Wood, J.; Lach, G.; Mietzsch, M.; Weger, S.; Heilbronn, R.; Herzog, H.; Bonaventure, P.; Sperk, G.; Tasan, R. NPY Y2 receptors in the central extended amygdala are crucially involved in fear conditioning and extinction. Neuropharmacology (2015), 99: 665-74, doi: 10.1016/j.neuropharm.2015.08.038.

Lach, G.; De Lima, T.C.M. Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning: dissociation between anxiety, locomotion and non emotional memory behavior. Neurobiol Learn Mem (2013), 103: 26-33, doi: 10.1016/j.nlm.2013.04.005.

Dos Santos, V.V.; Santos, D.B.; Lach, G.; Rodrigues, A.L.; Farina, M.; De Lima, T.C.M; Prediger, R.D. Neuropeptide Y (NPY) prevents depressive-like behavior, spatial memory deficits and oxidative stress following amyloid-β (Aβ_1–40) administration in mice. Behav Brain Res (2013), 244: 107-115, doi: 10.1016/j.bbr.2013.01.039.

Duarte, F.S.; Lach, G.; Martins, P.R.C.; Romeiro, G.A.; De Lima, T.C.M. Evidence for the involvement of the monoaminergic system in the antidepressant-like action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry (2008), 32(2): 368-374, doi:10.1016/j.pnpbp.2007.08.042.