My research focuses on the study of the impact that chemotherapeutic drugs have on the male and female reproductive tissues. Contact type Person First name Federica Surname Lopes Role Postdoctoral Research Assistant Organisation 1 Hugh Robson Building Organisation 2 15 George Square Organisation 3 Edinburgh, EH8 9XD Work phone +44 (0)131 650 3105 Email Federica.Lopes@ed.ac.uk Personal profile 2013 – present: Postdoctoral researcher, Centre for Integrative Physiology, University of Edinburgh, UK. 2011 – 2013: Research Assistant, Centre for Integrative Physiology, University of Edinburgh, UK. 2009 – 2011: Veterinary Laboratory Assistant, Institute Caporale, Teramo, Italy. 2007: PhD in Production , Reproduction and Animal Welfare at the University of Sassari, Italy. 2003: Degree in Veterinary Medicine at the University of Teramo, Italy. Research The extraordinary achievements reached in cancer therapies during the last decades have prolonged life expectancy of patients. For that reason, nowadays, studies need to be devoted for minimising negative side effects of cancer survivors. Understanding the effect of chemo drugs on the principal cells of the reproductive system, the gametes, is the first step towards the development of strategies for their protection. Each class of drugs tested so far in our lab has displayed a drug-specific mechanism of action, with male and female gametes also showing different sensitivities to drug exposure. My aim is to investigate these mechanisms and ultimately to explore protective strategies of fertility in cancer patients. Funding Medical Research Council (MRC) Collaborators Prof Richard Anderson, University of Edinburgh Dr Rod Mitchell, University of Edinburgh Dr Marie McLaughlin, University of Edinburgh Prof Evelyn Telfer, University of Edinburgh Prof Kate Hardy, Imperial College London Recent publications Morgan S., Lopes F., Gourley C., Anderson RA., Spears N. Cisplatin and doxorubicin induce distinct mechanism of ovarian follicle loss; Imatinib provides selective protection only against cisplatin. PLos One, 2013. PLos One article Lopes F., vannoni A., Sestini S., Casciaro A, Carducci A., bartolommei S., Toschi P., Ptak G., Cintorino M., Arcuri F. Sheep (Ovis aries) Macrophage migration inhibitory factor: molecular cloning, characterization, tissue distribution and expression in the ewe reproductive tract and in the placenta. Cytokine, 2011 Cytokine article This article was published on 2022-10-17
Contact type Person First name Federica Surname Lopes Role Postdoctoral Research Assistant Organisation 1 Hugh Robson Building Organisation 2 15 George Square Organisation 3 Edinburgh, EH8 9XD Work phone +44 (0)131 650 3105 Email Federica.Lopes@ed.ac.uk
