Stephen P Currie
My research concerns the neural representation of movement in primary motor cortex. In particular, I am interested in exploring the neural basis of motor directionality – ie movement of a limb in particular direction.
- 2016 – present Postdoctoral fellow – CDBS, Ian Duguid.
- 2015 - 2016 Postdoctoral researcher – CIP, Nathalie Rochefort.
- 2013 - 2015 Postdoctoral fellow – CIP, Michael Daw.
- 2009 - 2013 Ph.D in Neuroscience – University of St Andrews, Keith Sillar.
- 2005 - 2009 B.Sc Neuroscience – University of St Andrews.
My current research concerns the neural representation of movement in primary motor cortex. In particular, I am interested in exploring the neural basis of motor directionality – ie movement of a limb in particular direction.
I will combine 2-photon calcium imaging and patch-clamp electrophysiology in order to investigate both the cellular and population-level computations underpinning these movements.
Since dexterous movements depend on tight regulation of direction, the results of this study should inform us about a crucial aspect of motor control.
Henschke JU, Dylda E, Katsanevaki D, Dupuy N, Currie SP, Amvrosiadis T, Pakan JMP, & Rochefort NL (2020). Reward Association Enhances Stimulus-Specific Representations in Primary Visual Cortex. Current Biology.
Pakan JMP, Currie SP, Fischer L & Rochefort, NL (2018).'The Impact of Visual Cues, Reward, and Motor Feedback on the Representation of Behaviorally Relevant Spatial Locations in Primary Visual Cortex.' Cell Reports. https://doi.org/10.1016/j.celrep.2018.08.010.
Currie SP & Sillar KT (2017). ‘Developmental changes in spinal neuronal properties, motor network configuration and neuromodulation at free-swimming stages of Xenopus frog tadpoles.’ Journal of Neurophysiology. doi: 10.1152/jn.00219.2017.
Luz LL, Currie SP & Daw MI (2017). ‘Alterations in the properties of neonatal thalamocortical synapses with time in in vitro slices.’ PLoS ONE. doi:10.1371/journal.pone.0171897.
Currie SP, Luz LL, Booker SA, Kind PC & Daw MI (2017). ‘Reduced Local Input to Fast-Spiking Interneurons of the Developing Somatosensory Cortex in the GABAA γ2 R43Q Model of Absence Epilepsy.' Epilepsia. doi: 10.1111/epi.13693.
Pakan JMP, Lowe SC, Dylda E, Keemink SW, Currie SP, Coutts CA, & Rochefort NL (2016). ‘Behavioural state modulation of inhibitory neurons in mouse V1 is context-dependent and cell-type specific.’ eLife. doi: http://dx.doi.org/10.7554/eLife.14985.
Croker-Buque A, Currie SP, Luz LL, Duffy KR, Kind PC & Daw MI (2016). ‘Altered Thalamocortical Development in the SAP102 Knockout Model of Intellectual Disability.’ Hum. Mol. Genet. doi: 10.1093/hmg/ddw244
Currie SP, Doherty GH & Sillar KT (2016). ‘Deep-brain photoreception links luminance detection to motor output in pro-metamorphic Xenopus tadpoles.’ Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1515516113
Currie SP, Combes D, Scott NW, Simmers J & Sillar KT (2016). 'A behaviourally-related developmental switch in nitrergic modulation of locomotor rhythmogenesis in larval Xenopus tadpoles.' Journal of Neurophysiology. doi: 10.1152/jn.00283.2015.