Centre for Discovery Brain Sciences
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Sam A. Booker

My current research is focused on neuronal and synaptic structure and function in the developing mammalian forebrain, with a particular focus on the function of inhibitory neurons.

Dr Sam A. Booker

Postdoctoral Research Fellow

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh EH8 9XD

Contact details

Personal profile

  • Postdoctoral Research Fellow, University of Edinburgh, 2014 – Present.
  • Postdoctoral Researcher, NeuroCure, Berlin,  2011 – 2014.
  • PhD, University of Glasgow, UK.

Research

My current research is focused on neuronal and synaptic structure and function in the developing mammalian forebrain, with a particular focus on the function of inhibitory neurons. This is framed in the context of neurodevelopmental disorders, where subtle changes in synapse structure and function lead to long term alterations in neuronal circuit function.

I use a combination of electrophysiological recording techniques (whole cell and field recordings) with multi-photon imaging and caged neurotransmitter release to assess synaptic function. I assess neuronal structure with a multifaceted approach, utilising conventional and super-resolution light microscopy, as well as electron microscopy.

Relevant publications

Booker SA and Vida I (2018) Morphological Diversity and Connectivity of Hippocampal Interneurons. Tissue and Cell Research.

Booker S A, Loreth D, Gee, AL, Watanabe, M, Kind PC, Wyllie DJA, Kulik A and Vida I (2018) Postsynaptic GABAB receptors inhibit L-type calcium channels and abolish long-term potentiation in hippocampal somatostatin interneurons. Cell Reports. 

Booker SA and Wyllie DJA (2017) Parvalbumin interneurons in the dorsal horn: it's not all about GABA. Journal of Physiology (invited commentary).

Booker SA, Althof D, Degro CE, Watanabe M, Kulik A, Vida I (2017) Differential surface density and modulatory effects of presynaptic GABAB receptors in hippocampal cholecystokinin and parvalbumin basket cells. Brain Structure and Function.

Booker SA and Vida I (2018) Morphological Diversity and Connectivity of Hippocampal Interneurons. Tissue and Cell Research.

Booker S A, Loreth D, Gee, AL, Watanabe, M, Kind PC, Wyllie DJA, Kulik A and Vida I (2018) Postsynaptic GABAB receptors inhibit L-type calcium channels and abolish long-term potentiation in hippocampal somatostatin interneurons. Cell Reports.

Booker SA and Wyllie DJA (2017) Parvalbumin interneurons in the dorsal horn: it's not all about GABA. Journal of Physiology (invited commentary).

Booker SA, Althof D, Degro CE, Watanabe M, Kulik A, Vida I (2017) Differential surface density and modulatory effects of presynaptic GABAB receptors in hippocampal cholecystokinin and parvalbumin basket cells. Brain Structure and Function.