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Dr Philip Hasel

Dr Philip Hasel's staff profile and research interests.

Dr Philip Hasel

Postdoctoral Research Fellow - Hardingham Group

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh, EH8 9XD

Contact details

Personal profile 

  • 2017-present: Postdoc, University of Edinburgh
  • 2012-2017: PhD in Neuroscience, University of Edinburgh
  • 2010-2012: Master of Science, University of Heidelberg
  • 2007-2010: Bachelor of Science, University of Maastricht

Research

I study how neurons signal to astrocytes and how this is perturbed in disease. I am currently looking into ways of increasing the neurosupportive properties of astrocytes to ultimately confer non-cell autonomous neuroprotection in neurodegenerative diseases.

Relevant Publications 

J. Qiu*, O. Dando*, P.S. Baxter, P. Hasel, […], G.E. Hardingham “Mixed species RNA-seq for elucidating non cell-autonomous control of gene transcription” Nat. Protocols (in press)

P. Hasel, […], G.E. Hardingham “Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.,” Nat Commun, vol. 8, p. 15132, May 2017.

N. M. Márkus, P. Hasel, […], G.E. Hardingham “Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling,” PLoS ONE, vol. 11, no. 2, p. e0148164, Feb. 2016.

J. R. K. Marland, P. Hasel, K. Bonnycastle, and M. A. Cousin “Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals.,” JBC, Dec. 2015.

K. F. S. Bell, B. Al-Mubarak, M.-A. E. Martel, S. Mckay, N. Wheelan, P. Hasel, […] G.E. Hardnigham “Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2,” Nat Commun, vol. 6, pp. 1–15 May 2015.

P. S. Baxter, K. F. S. Bell, P. Hasel, […] G.E. Hardingham “Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system.,” Nat Commun, vol. 6, p. 6761, Mar. 2015.

P. Hasel, S. Mckay, J. Qiu, and G. E. Hardingham, “Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons.,” BBA - MRC, pp. 1–11, Dec. 2015.