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Dr. Katy Marshall-Phelps

My research focuses on understanding the mechanisms by which damage to the myelinated axonal tracts in our central nervous system occurs during Multiple Sclerosis and in identifying potential remyelinating and neuroprotective therapies.

Dr Katy Marshall-Phelps

Postdoctoral Research Fellow

  • Chancellor's Building
  • 49 Little France Crescent
  • Edinburgh EH16 4SB

Contact details

Personal Profile

  • 2021-present Postdoctoral researcher, MS Society Edinburgh Centre for MS Research.
  • 2014-2021 Postdoctoral researcher in the group of Prof David Lyons. University of Edinburgh.
  • 2013-2014 Associate Medical Writer with McCann Medical Communications. Glasgow.
  • 2009 - 2013 PhD Neuroscience in the group of Prof Peer Wulff. University of Aberdeen.
  • 2004-2009 BSc Hons in Biomedical Sciences. University of Aberdeen.

Research 

My research focuses on understanding the mechanisms by which damage to the myelinated axonal tracts in our central nervous system occurs during Multiple Sclerosis and in identifying potential remyelinating and neuroprotective therapies. As part of the MS Centre at the University of Edinburgh, we are developing a drug screening platform integrating multiple human and animal models to identify novel compounds for the treatment of MS.

Relevant Publications 

  • Moyon, S., Frawley, R., Marechal, D., Dennis, H., Marshall-Phelps, K.L.H., Kegel, L., Bøstrand, S.M.K., Sadowski, B., Jiang, Y-H., Lyons D.A., Möbius, W & Casaccia, P. TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice. (2021). Nature Communications, 12(1):3359.
  • Marshall-Phelps, K.L.H., Kegel, L., Baraban, M., Ruhwedel, T., Gois De Almeida, R., Rubio-Brotons, M., Klingseisen, A., Benito-Kwiecinski, S.K., Early, J., Bin, J., Suminaite, D., Livesey, M., Mobius, W., Poole, R.J. & Lyons, D. Neuronal activity disrupts myelinated axon integrity in the absence of NKCC1b. (2020). Journal of Cell Biology, 219 (7):1-12.
  • Marshall-Phelps, K.L.H., Riedel, G., Wulff, P & Woloszynowska-Fraser, M. Cerebellar molecular layer interneurons are dispensible for cued and contextual fear conditioning. (2020). Scientific Reports, 10(1)
  • Yang, Z., Cole, K.L.H., Qiu Y., Somorjai, I.M.L., Wijesinghe, P., Nylk, J., Cochran, S., Spalding, G.C., Lyons, D.A, Dholakia, K. Light sheet microscopy with acoustic sample confinement. (2019). Nature Communications, 10(1):669.
  • Early J,J*., Marshall-Phelps, K.L.H*., Williamson, J.M., Swire, M., Kamadurai, H., Muskavitch, M., Lyons, D.A. An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination. (2018). eLife, pii: e35136.
  • Almeida, R.G., Pan, S., Cole, K.L.H., Williamson, J.M., Early, J,J., Czopka, T., Klingseisen, A, Chan, J.R., Lyons, D.A. Myelination of Neuronal Cell Bodies when myelin sheaths exceeds axonal demand. (2018). Current Biology.
  • Cole, K.L.H., Early, J.J., Lyons, D.A. Drug discovery for remyelination and treatment of MS. (2017). Glia, 65(10):1565-1589. Review.

*Equal Contribution.