Centre for Discovery Brain Sciences
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Declan King

We aim to characterise changes in brain structure in old age and investigate relationships between brain ageing and cognitive decline using a unique and extremely well-characterised model of healthy ageing (LBC 1936 cohort).

Dr Declan King

Postdoctoral Associate

  • 1 George Square
  • Edinburgh
  • EH8 9JZ

Contact details

Personal profile

2018 - Present: Postdoctoral Associate, University of Edinburgh.

2017 - 2018: Full time PhD, University of Edinburgh.

2016 – 2017: Research Fellow/ Part time PhD, Roslin Institute, University of Edinburgh.

2008 – 2016: Senior Research Scientist/ Part time PhD, Roslin Institute, University of Edinburgh.

2002 – 2008: Research Technical Scientist, Neuropathogenesis Unit, Edinburgh.

Research

We aim to characterise changes in brain structure in old age and investigate relationships between brain ageing and cognitive decline using a unique and extremely well-characterised model of healthy ageing (LBC 1936 cohort). Our hypothesis is that synaptic resilience in the form of robust synaptic numbers, structure and molecular composition underpins successful or healthy cognitive ageing. 

Recent publications

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype 2019. R Hesse; Maica Llavero Hurtado; Rosemary J. Jackson; Samantha L. Eaton; Abigail G Herrmann; Marti Colom-Cadena; Declan King; Jamie Rose; Jane Tulloch; Chris-Anne McKenzie; Colin Smith; Christopher Henstridge; Douglas Lamont; T M Wishart; T L Spires-Jones, DPhil Acta Neuropathologica Communications.

Declan King
Figure 1: Reconstruction of synaptic interactions (green/red) with an amyloid plaque (blue) in the brain. We aim to investigate synaptic densities and interactions with amyloid and tau in both healthy and AD brains to gain insights into synaptic resilience and healthy ageing.