Centre for Discovery Brain Sciences
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Daniela Ivanova

The molecular mechanisms of trafficking of cargos specific for ADBE.

 

Dr Daniela Ivanova

Postdoctoral Research Fellow

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh EH8 9XD

Contact details

Personal profile

  • 2006 – 2008:  Master student of Molecular Biology: Biochemistry at Sofia University ‘St. Kliment Ohridski’, Bulgaria.
  • 2009 –2015: PhD student in the research group of Prof. Dr. Eckart D. Gundelfinger, Leibniz- Institute for Neurobiology, Magdeburg, Germany.
  • 20015 –2017: Postdoctoral fellow in the research group of Prof. Dr. Eckart D. Gundelfinger and Dr. Anna Fejtova, Leibniz- Institute for Neurobiology, Magdeburg, Germany.
  • Since 2017: Postdoctoral Research Fellow in the group of Prof. Mike Cousin, University of Edinburgh. 

Research

Activity-dependent bulk endocytosis (ADBE) is the main pathway for membrane retrieval in the presynaptic terminal during high-frequency neuronal firing. My research focuses on studying the molecular mechanisms of trafficking of cargos specific for ADBE and understanding the physiological role of this endocytic mode at the presynapse.

Publications

Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo  - Daniela Ivanova, Anika Dirks, Carolina MontenegroVenegas, Cornelia Schöne, Wilko Altrock, Claudia Marini, Renato Frischknecht, Denny Schanze, Martin Zenker,Eckart D Gundelfinger, Anna Fejtova, The EMBO Journal (2015) 34, 1056-1077. 

Bassoon and piccolo regulate ubiquitination and link presynaptic molecular dynamics with activity-regulated gene expression - Daniela Ivanova, Anika Dirks, Anna Fejtova, The Journal of Physiology, 2016 Oct 1;594(19):5441-8.

Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling -  Vesna Lazarevic, Sandra Fienko, Maria Andres-Alonso, Daniela Anni, Daniela Ivanova, Carolina Montenegro-Venegas, Eckart D Gundelfinger, Mike A Cousin, Anna Fejtova, Front Mol Neurosci. 2017 Jul 21;10:221.