Centre for Discovery Brain Sciences
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Chris Henstridge

Synaptic alterations feature in many neurological conditions and this has been a central focus throughout my postgraduate research.

Dr Christopher Henstridge

Senior Postdoctoral Associate

  • 1 George Square
  • Edinburgh, EH8 9JZ

Contact details

Personal profile

  • 2017 - Present  Senior Postdoctoral Associate, Centre for Discovery Brain Sciences, University of Edinburgh.
  • 2014 - 2017  Postdoctoral Associate, Centre for Cognitive and Neural Systems, University of Edinburgh.
  • 2012 - 2014  Postdoctoral Fellow, KOKI, Hungarian Academy of Sciences, Budapest.
  • 2010 - 2012  EMBO Long-Term Fellow, KOKI, Hungarian Academy of Sciences, Budapest.
  • 2005 - 2010  PhD Pharmacology and Neuroscience, University of Dundee.
  • 2000 - 2005  MSci Pharmacology, University of Glasgow.

Research

Synaptic alterations feature in many neurological conditions and this has been a central focus throughout my postgraduate research. I spent my first postdoctoral position in the lab or Dr. Istvan Katona in Budapest, assessing the nanoscale distribution of synaptic proteins in a mouse model of Fragile X Syndrome, funded by an EMBO long-term fellowship. With the aim of building upon my technical expertise, I moved to the lab of Dr. Tara Spires-Jones in 2014 and in 2016 was awarded a 3yr project grant from MND Scotland as lead-applicant. I apply high-resolution imaging techniques such as electron microscopy and  array tomography, to examine the structure and function of synapses in healthy and diseased brain. Since arriving in 2014 I have helped build the world’s first brain bank of human tissue prepared for the array tomography technique. My projects are highly interdisciplinary, involving collaboration with colleagues in psychology, neuropathology, neuroimaging, and genetics both within the University of Edinburgh and worldwide.

Human Imaging

Recent publications

  • Henstridge, C.M., Hyman, B.T. and Spires-Jones, T.L. (2018) Beyond the neuron - Cellular interactions early in Alzheimer’s disease pathogenesis. Nature Reviews Neuroscience. In press.
  • Pickett, E.K., Rose, J., McCrory, C., McKenzie, C-A.,King, D., Smith, C., Gillingwater, T.H., Henstridge, C.M., Spires-Jones, T.L. (2018) Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease. Acta Neuropathologica. In press.
  • Hesse, R and Henstridge, C.M. (2018) FENSKavli winter symposium: addressing the cellular phase of dementia visions of the UK Dementia Research Institute. European Journal of Neuroscience. In press.
  • Henstridge, C.M. and Spires-Jones, T.L. (2018) Modeling an Alzheimer’s disease brain in a dish. Nature Neuroscience – News and Views. In press.
  • Henstridge, C.M., Sideris, D.I., Carroll, E., Rotariu, S., Salomonsson, S., Tzioras, M., McKenzie, C.A., Smith, C., von Arnim, C.A.F., Ludolph, A.C., Lulé, D., Leighton, D., Warner, J., Cleary, E., Newton, J., Swingler, R., Chandran, S., Gillingwater, T.H., Abrahams, S. and Spires-Jones, T.L. (2017) Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis. Acta Neuropathol, in press.
  • Colom-Cadena, M., Pegueroles, J., Herrmann, A., Henstridge, C.M., Munoz, L., Querol-Vilaseca, M., Luque-Cabecerans, J., Belbin, O., Smith, C., McKenzie, C-A., Roy, A., Fortea, J., Gelpi, E., Hyman, B.T., Spires-Jones, T. and Lleo, A. (2017) Synaptic p-α-synuclein in dementia with Lewy bodies. Brain, 1;140(12):3204-3214.
  • Tzioras, M., Easter, J., Harris, S., McKenzie, C-A., Smith, C., Deary, I., Henstridge, C.M.* and Spires-Jones, T.* (2017) Assessing amyloid-beta, tau and glial features in Lothian Birth Cohort 1936 participants post-mortem. Science Matters. DOI: 10.19185/matters.201708000003 (* = equal contribution).
  • Paolicelli, R.C., Jawaid, A., Henstridge, C.M., Valeri, A., Merlini, M., Robinson, J.L., Lee, E.B., Rose, J., Appel, S., Lee, V.M.-Y, Trojanowski, J.Q., Spires-Jones, T., Schulz, P.E. and Rejendran, L. TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss. (2017) Neuron, 95 (2), 297-308.
  • Pickett, E.K., Henstridge, C.M., Pitstick, R., Pooler, A., Wegmann, S., Carlson, G., Hyman, B. and Spires-Jones, T.L. (2017) Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer’s disease. Synapse. e21965.
  • Pickett, E.K., Koffie, R.M., Wegmann, S., Henstridge, C.M., Herrmann, A.G., Colom-Cadena, M., Lleo, A., Kay, K.R., Vaught, M., Soberman, R., Walsh, D.M., Hyman, B. and Spires-Jones, T.L. (2016) Non-fibrillar oligomeric amyloid-beta within synapses. Journal of Alzheimers Disease. 53: 787-800.
  • Henstridge, C.M., Jackson, R.J., Kim, J.S., Herrmann, A.G., Wright, A.K., Harris, S., Bastin, M.E., Starr, J.M., Wardlaw, J.M., Gillingwater, T.H., Smith, C., McKenzie, C., Cox, S.R., Deary, I.J. and Spires-Jones, T.L. (2015) Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse. Acta Neuropathologica Communications. 3:53.
  • Jung*, K.M., Sepers*, M., Henstridge*, C.M., Lassalle, O., Neuhofer, D., Martin, H., Ginger, M., Frick, A., DiPatrizio, N.V., Mackie, K., Katona, I., Piomelli, D. and Manzoni, O. (2012) Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nature Communications 3:1080 doi: 10.1038/ncomms2045 (* - equal contribution).
  • Henstridge, C.M., Balenga, N.A., Schroder, R., Kargl, J.K., Platzer, W., Martini, L., Arthur, S., Penman, J., Whistler, J.L., Kostenis, E., Waldhoer, M. and Irving, A.J. (2010) GPR55 ligands promote receptor coupling to multiple signalling pathways. British Journal of Pharmacology 160 (3), 604-614.
  • Henstridge, C.M., Balenga, N.A.B., Ford, L.A., Ross, R.A., Waldhoer, M. and Irving, A.J. (2009) The GPR55 ligand L-α-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signalling and NFAT activation. FASEB Journal Jan; 23(1), 183-193