Centre for Discovery Brain Sciences
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Adrian Olmos-Alonso

Adrian Olmos-Alonso's contact details and research

Mr Adrian Olmos-Alonso

Research Fellow - McColl Lab

  • The Chancellors Building
  • 49 Little France Crescent
  • Edinburgh, EH16 4SB

Contact details

Personal profile

  • 2018-Present: Research Fellow, University of Edinburgh
  • 2016-2017: Research Manager, “San Carlos” Health Research Institute (IdISSC)
  • 2013-2016: Research Technician, University of Southampton

Research

Stroke is a leading cause of death and long-term disability yet only a tiny minority of patients can benefit from existing hyperacute reperfusion treatments due to the short time window. Thus, a major clinical need is to develop alternative/adjunct therapies that can be applied over a longer timespan to allow many more patients to be treated. A key approach is to potentiate the inherent capacity of the injured brain to repair and promote functional recovery. In particular, treatments that can harness/augment the endogenous pro-repair properties of microglia/macrophages will improve functional recovery after stroke.

Relevant publications

  • Askew K, Li K, Olmos-Alonso A, Garcia-Moreno F, Liang Y, Richardson P, Tipton T, Chapman MA, Riecken K, Beccari S, Sierra A, Molnár Z, Cragg MS, Garaschuk O, Perry VH, Gomez-Nicola D. Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain. Cell Rep 2017; 18(2):391-405.
  • Martínez-Muriana A, Mancuso R, Francos-Quijorna I, Olmos-Alonso A, Osta R, Perry VH, Navarro X, Gomez-Nicola D, López-Vales R. CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves. Sci Rep 2016; 6:25663.
  • Bisht K, Sharma KP, Lecours C, Sánchez MG, El Hajj H, Milior G, Olmos-Alonso A, Gómez-Nicola D, Luheshi G, Vallières L, Branchi I, Maggi L, Limatola C, Butovsky O, Tremblay MÈ. Dark microglia: A new phenotype predominantly associated with pathological states. Glia 2016; 64(5):826-39.
  • Olmos-Alonso A, Schetters ST, Sri S, Askew K, Mancuso R, Vargas-Caballero M, Holscher C, Perry VH, Gomez-Nicola D. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology. Brain 2016; 139(Pt 3):891-907.
  • De Lucia C, Rinchon A, Olmos-Alonso A, Riecken K, Fehse B, Boche D, Perry VH, Gomez-Nicola D. Microglia regulate hippocampal neurogenesis during chronic neurodegeneration. Brain Behav Immun 2016; 55:179-190.