Shinjini Basu's staff profile and research.
- 2015-Present – PhD Biomedical Sciences (Integrative Physiology) at the University of Edinburgh
- 2014-2015 – MSc by Research Biomedical Sciences (Integrative Physiology) at the University of Edinburgh
- 2010 – 2014 – BSc Honours Biomedical Sciences (Medical Sciences) at the University of Edinburgh
Abnormalities in sensory processing and increased seizure susceptibility are core symptoms associated with Autism spectrum disorders and intellectual disability (ASD/ID). Numerous cellular changes contribute to these phenotypes, however, a key regulator of cellular excitability, the axon initial segment (AIS), has not been previously examined. The AIS is the site of action potential generation and as such plays a critical role in regulating cellular excitability. My project directly tests the hypothesis that changes in the AIS length contribute to altered cellular excitability and explores the idea of convergence of diverse genetic causes on common cellular pathways. To this effect, we have measured alterations in AIS length across multiple brain regions in six distinct mutations in synaptic-proteins known to cause ASD/ID including Fmr1, Syngap, Neuroligin-3, Neurexin-1, PTen and Cntnap2.
Brown S. S. G., Basu S, Whalley H.C., Kind P. C., Stanfield A. C. Age-related functional brain changes in FMR1premutation carriers NeuroImage: Clinical (2017)