Shinjini Basu's staff profile and research. Contact type Person First name Shinjini Surname Basu Role PhD Student - Kind Lab Organisation 1 Hugh Robson Building Organisation 2 15 George Square Organisation 3 EH8 9DX Work phone +44 (131) 650 3741 Email S1002974@sms.ed.ac.uk Personal Profile 2015-Present – PhD Biomedical Sciences (Integrative Physiology) at the University of Edinburgh 2014-2015 – MSc by Research Biomedical Sciences (Integrative Physiology) at the University of Edinburgh 2010 – 2014 – BSc Honours Biomedical Sciences (Medical Sciences) at the University of Edinburgh Research Abnormalities in sensory processing and increased seizure susceptibility are core symptoms associated with Autism spectrum disorders and intellectual disability (ASD/ID). Numerous cellular changes contribute to these phenotypes, however, a key regulator of cellular excitability, the axon initial segment (AIS), has not been previously examined. The AIS is the site of action potential generation and as such plays a critical role in regulating cellular excitability. My project directly tests the hypothesis that changes in the AIS length contribute to altered cellular excitability and explores the idea of convergence of diverse genetic causes on common cellular pathways. To this effect, we have measured alterations in AIS length across multiple brain regions in six distinct mutations in synaptic-proteins known to cause ASD/ID including Fmr1, Syngap, Neuroligin-3, Neurexin-1, PTen and Cntnap2. Relevant Publications Brown S. S. G., Basu S, Whalley H.C., Kind P. C., Stanfield A. C. Age-related functional brain changes in FMR1premutation carriers NeuroImage: Clinical (2017)
Contact type Person First name Shinjini Surname Basu Role PhD Student - Kind Lab Organisation 1 Hugh Robson Building Organisation 2 15 George Square Organisation 3 EH8 9DX Work phone +44 (131) 650 3741 Email S1002974@sms.ed.ac.uk