Functional development of head direction cells in a rat model of autism and intellectual disability.
- 2015-2019 - BSc Biomedical Sciences (Honours Neuroscience), University of Edinburgh
My project involves investigating the functional development of head direction cells in a rat model of autism and intellectual disability. The development of connections relaying information from the thalamus to the cortex has been implicated in the pathology of Fragile X Syndrome (FXS), one of the leading causes of autism. These connections are necessary for the normal development of the head direction sense, which is key for spatial cognition. I am employing large scale in vivo electrophysiology to examine how head direction cells might be affected in rats modelling this syndrome at different developmental stages.