Nina Kozar's biography and research focus.
- BBSRC EASTBIO PhD in Neuroscience (University of Edinburgh, 2017-present)
- BSc (Hons) in Immunology (The University of Glasgow, 2013-2017)
- Honours laboratory project - ‘Harnessing antigen size to drive vaccine responses’ (The University of Glasgow, September-December 2016)
- Wellcome Trust Vacation Studentship - ‘Microglial involvement in antibody-mediated type I interferon-like responses in the Central Nervous System’ (The University of Glasgow, July-September 2016)
My project focuses on the molecular and cellular mechanisms that govern the stereotypic distribution of voltage gated potassium channels (Kv) within myelinated axons. Defective distribution of these complexes in the nervous system has been implicated in many neurological disorders such as ataxia and epilepsy.
Previous research has suggested that interactions between CASPR2 and TAG-1 drive the assembly of Kv channels at the juxtaparanodal membrane (JXP) of myelinated axons (Horresh et al. 2010). However, preliminary data from the Meijer lab have shown that Kv1 complex assembly and stability at the JXP critically depends on ADAM23 and its ligands LGI2 and LGI3.
In this research project, we will establish how these proteins contribute to the assembly and maintenance of Kv channel complexes in both myelinating axons as well as in remyelinating axons following nerve injury.