I am investigating whether normal astrocytic functions are altered in Alzheimer’s Disease (AD).
- Wellcome Trust 4 Year Translational Neuroscience PhD student (2016-present)
- Pharmacology Msci, University of Bristol (2012-2016)
- Industrial placement at Pfizer (2014-2015)
Astrocytes are the most abundant cell type in the brain. They are involved in a number of functions, including providing nutrients to nervous tissue and regulating extracellular ion balance. I am investigating whether normal astrocytic functions are altered in Alzheimer’s Disease (AD). I am utilising in vitro and in vivo models of AD to conduct unbiased searches for alterations in astrocytic gene expression in the context of synapse loss. I will compare these results to those found in human AD cases to assess the suitability of these models.