Centre for Discovery Brain Sciences
Centre for Discovery Brain Sciences Transparent Logo

Makis Tzioras

Makis Tzioras's biography and research focus.

Mr Makis Tzioras

PhD Student

  • UK Dementia Research Institute
  • 1 George Square & Chancellor's Building
  • Edinburgh

Contact details

Personal Profile

  • DRI funded PhD, Cognitive and Neural Systems, University of Edinburgh (2017-present)
  • BSc Biomedical Sciences (Honours Neuroscience), University of Edinburgh (2013-2017)

Research

Figure 1. GFAP-positive astrocytes (red) and synaptophysin (green) from human control tissue showing synaptic engulfment. Tissue processed by array tomography.
Figure 1. GFAP-positive astrocytes (red) and synaptophysin (green) from human control tissue showing synaptic engulfment. Tissue processed by array tomography.

My project involves investigating glial resilience mechanisms and their effects on synaptic degeneration in Alzheimer’s disease (AD). Synapse loss is the best correlate to cognitive decline in AD, and there is accumulating evidence to show that microglia and astrocytes, the brain’s immune cells, play a critical role in synapse elimination. The focus of my research is deciphering the mechanisms that prime glial cells to aberrantly prune synapses, and investigate how AD risk genes, like APOE and TREM2, affect this process.

 

Relevant Publications 

  • Henstridge, C., Sideris, D., Carroll, E., Rotariu, S., Salomonsson, S., Tzioras, M., McKenzie, C., Smith, C., von Arnim, C., Ludolph, A., Lulé, D., Leighton, D., Warner, J., Cleary, E., Newton, J., Swingler, R., Chandran, S., Gillingwater, T., Abrahams, S. and Spires-Jones, T. (2017). Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis. Acta Neuropathologica, 135(2), pp.213-226.
  • Tzioras, M., Easter, J., Harris, S., McKenzie, C., Smith, C., Deary, I., Henstridge, C. and Spires-Jones, T. (2017). Assessing amyloid-β, tau, and glial features in Lothian Birth Cohort 1936 participants post-mortem. Matters.