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Kelda Chia

The early impact of macrophages on tumour development.

Kelda Chia

PhD Student - Sieger Group

  • The Chancellor's Building
  • 49 Little France Crescent
  • EH16 4SB

Contact details

Personal Profile

  • 2014 – present: PhD in Neuroscience, University of Edinburgh
  • 2013 – 2014: MSc (by Research) in Integrative Neuroscience, University of Edinburgh
  • 2009 – 2013: BSc in Neuroscience, University of St Andrews


Within the tumour microenvironment, macrophages contribute to a significant proportion of the tumour mass and have been demonstrated to promote tumour growth and expansion. However, their role in the earliest stages of tumour initiation and development remains unknown.

Therefore, the focus of my PhD has been to investigate the early impact of macrophages on tumour development, in particular the role of microglia and its impact within the brain tumour microenvironment.

Recent publications

Chia K., Mazzolini J., Mione M. & Sieger D. (2018) Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain. eLIFE, 7:e31918. DOI: https://doi.org/10.7554/eLife.31918

Mazzolini J., Chia K. & Sieger D. (2018) Isolation and RNA extraction of neurons, macrophages and microglia from larval zebrafish brains. J. Vis. Exp. (134), e57431, doi:10.3791/57431.