The early impact of macrophages on tumour development.
- 2014 – present: PhD in Neuroscience, University of Edinburgh
- 2013 – 2014: MSc (by Research) in Integrative Neuroscience, University of Edinburgh
- 2009 – 2013: BSc in Neuroscience, University of St Andrews
Within the tumour microenvironment, macrophages contribute to a significant proportion of the tumour mass and have been demonstrated to promote tumour growth and expansion. However, their role in the earliest stages of tumour initiation and development remains unknown.
Therefore, the focus of my PhD has been to investigate the early impact of macrophages on tumour development, in particular the role of microglia and its impact within the brain tumour microenvironment.
Chia K., Mazzolini J., Mione M. & Sieger D. (2018) Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain. eLIFE, 7:e31918. DOI: https://doi.org/10.7554/eLife.31918
Mazzolini J., Chia K. & Sieger D. (2018) Isolation and RNA extraction of neurons, macrophages and microglia from larval zebrafish brains. J. Vis. Exp. (134), e57431, doi:10.3791/57431.