Centre for Discovery Brain Sciences
Centre for Discovery Brain Sciences Transparent Logo

Kai Boon Tan

Kai Boon Tan's biography and research focus.

Mr Kai Boon Tan

PhD Student - Price Lab

  • Hugh Robson Building
  • 15 George Square
  • Edinburgh, EH8 9XD

Contact details

Personal Profile

  • 2017 – Present    University of Edinburgh PhD in Developmental Neurobiology
  • 2015 – 2016          Imperial College London Master in Biomedical Research (Immunotoxicology and Neuroscience)  
  • 2014 – 2015          Monash University Research and Teaching Assistant in Immunology
  • 2011 – 2014          Monash University BSc (1st Class Honors) Biomedical Sciences

Research

I study the molecular mechanisms underlying the mammalian neocortex development. In particular, I am interested in how the key transcription factor PAX6 drives glutamatergic fate in neural progenitors to ultimately generate functional glutamatergic neurons.

I employ multidisciplinary approaches including the cutting-edge single-cell transcriptomics, bioinformatics, organotypic culture and pharmacological treatments to tackle the aforementioned question.

 

Research Figure
Figure 1: Regional protection conferred by PAX6. We argue PAX6 is required to safeguard the glutamatergic fate by preventing neural progenitors in different neocortical regions from overreacting to the morphogens in the milieu.

Relevant Publications

[Poster presentation] Tan KB, Kozic Z, Dobolyi D, Manuel M, Mason JO, Price DJ (2020) “Cell fate decision during the embryonic neocortex development” Cold Spring Harbor Laboratory Meeting – Epigenetics and Chromatin

[Poster presentation] Tan KB, Kozic Z, Dobolyi D, Manuel M, Mason JO, Price DJ (2020) “PAX6 regulates cell fate in the developing embryonic neocortex” 14th EMBL Conference – Transcription and Chromatin

[Poster presentation] Tan KB, Kozic Z, Dobolyi D, Manuel M, Mason JO, Price DJ (2020) “PAX6: a transcriptional guardian for glutamatergic fate in the developing neocortex” 12th FENS Forum of Neuroscience [link][video]

[Poster presentation] Tan KB, Kozic Z, Manuel M, Mason JO, Price DJ (2019) “Roles of PAX6 in glutamatergic fate specification during forebrain development” Developmental Biology Gordon Research Conference, Massachusetts, US.

[Poster presentation] Tan KB, Manuel M, Mason JO, Price DJ (2018) “Roles of PAX6 and migratory interneurons in cortical fate specification” 11th FENS Forum of Neuroscience, Berlin, Germany.

[Oral presentation and conference proceeding] Tan KB, Reed DM, Zetterqvist A, Nikolakopoulou Z, Toe Q, Kirkby NS, Mitchell JA (2016) “Safety screening for cytokine storm-inducing biologics using cryopreserved BOECs and PBMCs” Proceedings of the British Pharmacological Society. [link]