Centre for Discovery Brain Sciences
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Injury and Repair

The Research Theme is exploring the cellular and molecular mechanisms that underpin cell and tissue differentiation, resilience to injury, and repair processes.

Highly differentiated tissues, such as the central nervous system, are constantly exposed to a variety of challenges.

These include mechanical injury, degeneration, inflammation, and uncontrolled growth. In this theme, groups cooperate to discover the cellular and molecular mechanisms that underpin cell and tissue differentiation, resilience to injury, and repair processes.

We employ a variety of cellular models, model organisms, and screening approaches. This maximises synergy between groups in making fundamental discoveries and expediting translation of these to clinical research.

 

Name Research interest
Becker, Catherina Development and regeneration of the zebrafish nervous system
Becker, Thomas Development and regeneration of the zebrafish nervous system
Brophy, Peter Molecular and cell biology of axon-glia interactions in health and disease
Fowler, Jill Mechanisms of neurodegeneration in stroke and dementia
Hall, Andrew Chondrocytes, cartilage and osteoarthritis
Herrgen, Leah Molecular and cellular mechanisms of brain repair
Paxton, Jennifer Musculoskeletal tissue engineering  
Ribchester, Richard Development, plasticity, degeneration, and regeneration of neuromuscular connections.
Sieger, Dirk Microglia-tumour interactions
Torsney, Carole Somatosensory plasticity
Wyllie, David Physiology and pharmacology of ion channels
Zhang, HongYan Locomotor control and rhythm generation in simple animal model systems