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Becker Group publish paper in Journal of Neuroscience

Research using zebrafish has revealed how key brain cells that are damaged in people with Parkinson’s disease can be regenerated.

Well done to PhD students Lindsey J. Caldwell and Nick O. Davies and Becker Group for their latest publication in Journal of Neuroscence: 

Becker Lab

Regeneration of dopaminergic neurons in adult zebrafish depends on immune system activation and differs for distinct populations

Despite the fact that zebrafish show a high propensity to regenerate neurons in the brain, this study reveals that not all types of dopaminergic neurons are functionally regenerated after specific ablation. Hence, in the same adult vertebrate brain, mechanisms of successful and incomplete regeneration can be studied. We identify progenitor cells for dopaminergic neurons and show that activating the immune system promotes proliferation of these cells. However, in some areas of the brain this only leads to insufficient replacement of functionally important dopaminergic neurons that later disappear. Understanding the mechanisms of regeneration zebrafish may inform interventions targeting regeneration of functionally important neurons, such as dopaminergic neurons, from endogenous progenitor cells in non-regenerating mammals.

News Coverage: 

The work has been covered by a BBC Radio Scotland interview, STV news (https://stv.tv/news/east-central/1436834-zebrafish-could-be-key-to-parkinson-s-disease-treatment/

BBC news (https://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-47827326) and others.

Related Links:

Journal article

Centre for Discovery Brain Sciences

Edinburgh Neuroscience

Dr Thomas Becker

 

Congratulations to all!