Centre for Comparative Pathology

Animal Models

Animal models of human disease have proved invaluable, in particular manipulation of the mouse genome using embryonic stem (ES) cells, transgene insertion, gene knockout and genome editing.

Pancreatic Intraepithelial Neoplasia (mouse)
Pancreatic Intraepithelial Neoplasia (mouse)

We have a great depth of experience in gene modification via mouse ES cells but we are also at the cutting edge of the use of rat ES cells to create rat models of disease.

Genome editing technologies, including  TALENs and CRISPRs, are used to modify the genomes of not only mice and rats but also pigs, sheep, chickens and zebrafish.

These provide new and powerful models for the understanding of pathology of human and veterinary disease.

 

Related Staff

Prof Mark Arends

Prof Richard Baldock

Dr Fiona Houston

Dr Barry McColl

Prof Elspeth Milne

Prof Colin Smith

Prof Bruce Whitelaw

 

External Collaborators

Dr David Adams

Dr Thomas Brenn

Dr Brian Hosie

Dr Caroline Thaung

Dr George Vassiliou

Dr Irene Papatheodorou

 

Links

Mouse Atlas of Embryonic Development

Edinburgh Mouse Atlas of Gene Expression

Wellcome Trust Sanger Institute