Small Vessel Disease (SVD)
Small vessel disease (SVD) of the brain relates to abnormalities of the tiny vessels known as arterioles, capillaries & venules & encompasses a range of neuroimaging, pathological, & associated clinical features.
Our research aims to determine the pathophysiology of cerebral small vessel disease including lacunar stroke, using medical imaging, particularly magnetic resonance, laboratory methods & clinical research methods in cohort studies & clinical trials.
We have pioneered developments in blood-brain barrier permeability & cerebrovascular reactivity imaging, as well as advanced image analysis methods for SVD, & integration of multi-modality DTI, spectroscopy, structural & blood flow imaging.
Current projects include cross sectional & longitudinal analysis of patients with stroke or cognitive presentations of SVD, to understand more about how & why SVD lesions develop & to develop treatments. These include the mild stroke study I, II & now III, the Foundation Leduq study of Sleep Apnoea, the UK Dementia Research Institute, SVD study (MSS3), the EU H2020 funded SVDs@Target studies of blood brain barriers & CVR (Investigate@SVD’s) & anti-hypertensive treatment (treat@SVD) & EPSRC funded studies of the retina & brain to detect early signs of SVD, & many studies of image analysis methods including developing approaches including industry collaborations funded by Innovative.
The RowFogo centre for research into Aging & the brain recognises this body of work & forms a hub for future SVD research in Edinburgh.
Lead SVD researcher
If you would like to discuss undertaking SVD research & collaborating with us, please contact our business manager, who will arrange a meeting with our SVD research lead.
Research staff with a SVD focus
- Prof Andrew Farrall
- David Rodriguez
- Ms Eleni Sakka
- Dr Fergus Doubal
- Dr Francesca Chappell
- Prof Ian Marshall
- Ms Iona Hamilton
- Dr Lizzie Hill
- Dr Lucia Ballerini
- Dr Maria Valdés Hernández
- Dr Mark Bastin
- Dr Michael Stringer
- Dr Michael Thrippleton
- Dr Rosalind Brown
- Dr Stewart Wiseman
- Dr Susana Munoz Maniega
- Dr Tom MacGillivray
Funding organisations & research groups
Relevant Edinburgh Imaging publications
24 May 19. Featured Paper. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage & cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
16 Apr 19. Featured Paper. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design & multicenter pilot study.