Myopathies & inflammation
Cardiomyopathies are diseases of the heart muscle, which can affect the heart’s size, shape, structure & function. Cardiomyopathies are frequently inherited. Other myopathic changes can alter aortic & other blood vessel wall structure.
We use MR to assess heart function as well as key aspects of cardiovascular disease. MR techniques such as T1-mapping allow us to quantify processes such as fibrosis. We have pioneered this work in assessing severity of aortic stenosis, both of the valve itself & throughout the myocardium.
Our group has pioneered the use of novel MR contrast agents to image processes directly, such as inflammation. Using iron-oxide based MR contrast agents (USPIOs), we have directly imaged inflammation within abdominal aortic aneurysms to help predict aneurysm rupture & understand growth patterns within these aneurysms. We have applied this technique to look at macrophage infiltration within the myocardium during heart remodelling following myocardial infarction & in a range of cardiomyopathies.
Finally we can image myocardial inflammation using the PET tracer 18F-fluciclatide to image integrin expression following myocardial infarction post myocardial infarction.
Lead myopathies & inflammation researcher
To discuss new research & collaborative imaging projects with Edinburgh Imaging, please contact:
Research staff with a myopathies & inflammation focus
Completed projects – more info to come.
Funding organisations & groups
More info to come.
Relevant Edinburgh Imaging publications