SMARTIS - Current trials

Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis

• Randomised-controlled trial comparing different types of thrombolytics for use in ischaemic stroke

INVESTIGATE-SVDs

Imaging NeuroVascular, Endothelial & STructural Integrity in prepAration to TrEat Small Vessel Diseases

• A MRI study at 3T to assess blood brain barrier function, microvascular function, & perivascular flow.

LACunar Intervention Trial-2

• Assessment of safety & efficacy of cilostazol & isosorbide mononitrate to prevent recurrent lacunar stroke & progression of cerebral small vessel disease.

Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured & High-risk Coronary Artery Plaques in Patients with Myocardial Infarction.

• Observational study assessing whether 18F-fluoride PET can improve risk stratification of patients presenting with myocardial infarction

Rates, Risks & Routes to Reduce Vascular Dementia

• Prospective clinical study evaluating the development of dementia among patients with stroke over at least 2 years.

REstart or STop Antithrombotics Randomised Trial

• Randomised controlled trial for adults surviving spontaneous intracerebral haemorrhage (ICH)who had taken an antithrombotic drug (i.e. anticoagulant or antiplatelet medication) for the prevention of vaso-occlusive disease before the ICH.

Start or Stop Anticoagulants Randomised Trial.

• Randomised-controlled trial for adults with atrial fibrillation after a brain haemorrhage

TREAT-SVDs

•  An interventional study to determine the effects of different blood pressure lowering agents on microvascular function in patients with distinct SVDs.