PET synaptic imaging resources
“Enabling advance imaging of synaptic function in living males and females over the course of the lifespan with Positron Emission Tomography (PET)”
The project aims to:
- generate synthetic routes and radiochemistry methods for efficient production of [18F]MNI1126;
- develop detailed template resources for quantitative analysis of SV2A PET signal in different brain regions over the course of natural aging in the rat and mouse; and
- validate SV2A PET in vivo outcomes at unprecedented scale and resolution using synaptome mapping technology.
Dr Adriana Tavares, Reader in PET imaging, together with Professors Andrew Sutherland and Seth Grant, were awarded funding through the Wellcome Trust Technology Development Award (TDA) scheme. The grant was created for researchers who wish to develop new technologies and tools.
The project, “Enabling advance imaging of synaptic function in living males and females over the course of the lifespan with Positron Emission Tomography (PET)” will run from the 1st October 2020 to 30th September 2025.
Application for material transfer
One of the project goals is to share resources with the wider imaging community, namely new materials and new datasets.
The materials available for transfer, following a successful application:
- MNI1126 organotin precursor and standard material. MNI1126 is also known as SDM-08 or SynVesT-1.
These materials, in the supplied quantities, will be enough for other groups to initiate SV2A PET research at their centres, therefore enhancing access to the technology, and it is intended to work as flagship support to subsequent large projects at various centres.
If you would like to request access to these materials, please complete the application form below.
Further information about the materials, the application process and how to submit are listed in the form.
PET is Wonderful (PiW) datasets
New datasets to be made available at different project’s milestones: SV2A PET template resources and synaptome map datasets developed in this project will be made fully available in formats compliant with general use (e.g. DICOM data in the case of PET scans) via Edinburgh DataShare for any researcher to re-use.
Click here for the “PET is Wonderful” collection at Edinburgh DataShare for updated content.
Additional imaging dataset requests can be made by email to: PiWTeam@ed.ac.uk