Edinburgh Imaging

16 Apr 19. Featured Paper

The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.

Link to paper on ScienceDirect.



Nick A. Weaver, Lei Zhao, J. Matthijs Biesbroek, Hugo J. Kuijf, Hugo P. Aben, Hee-Joon Bae, Miguel Á.A. Caballero, Francesca M. Chappell, Christopher P.L.H. Chen, Martin Dichgans, Marco Duering, Marios K. Georgakis, Ruben S. van der Giessen, Bibek Gyanwali, Olivia K.L. Hamilton, Saima Hilal, Elise M. vom Hofe, Paul L.M. de Kort, Peter J. Koudstaal, Bonnie Y.K. Lam, Jae-Sung Lim, Stephen D.J. Makin, Vincent C.T. Mok, Lin Shi, Maria C. Valdés Hernández, Narayanaswamy Venketasubramanian, Joanna M. Wardlaw, Frank A. Wollenweber, Adrian Wong, Xu Xin



Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies.


Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage.


Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage.


Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared.

Other investigators are welcome to join.

  • Cerebrovascular disease

  • Vascular cognitive impairment

  • Stroke

  • Small vessel disease

  • Consortium

  • Data harmonization

  • Support vector regression

  • Lesion-symptom mapping

  • Lesion location