Edinburgh Imaging

DEMAND-MI Cases

This educational resource provides access to the DEMAND-MI study cases including clinical history, coronary & structural imaging. The aim of this resource is to provide an overview of the clinical presentation & imaging findings in patients with type 2 myocardial infarction.

DEMAND-MI

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Study information / background

Determining the mechanism of myocardial injury & role of coronary disease in type 2 myocardial infarction (DEMAND-MI - NCT03338504) is the first prospective observational cohort study that aimed to determine the mechanism of myocardial injury & role of coronary disease in patients with type 2 myocardial infarction.

We invited one hundred (100) patients with a clinical diagnosis of type 2 myocardial infarction, who met study inclusion criteria, to take part. All patients provided written informed consent.

In all patients, we evaluated coronary anatomy by invasive or non-invasive (CT) coronary angiography dependent on co-morbidities & patient preference.

All patients who were without contraindications, underwent cardiovascular magnetic resonance (CMR) in a 3T MR scanner (MAGNETOM Verio, Siemens AG, Healthcare Sector, Erlangen, Germany). We used the late gadolinium enhancement & T2 mapping techniques to identify regions of new or old myocardial infarction as well as other patterns of injury, such as the mid-wall pattern associated with myocarditis.

An adjudication panel reviewed in detail, all patients' electronic healthcare records, including clinical documentation, routine clinical tests, & research imaging results.

 

Content

This DEMAND-MI educational resource will compile one hundred clinical vignettes for all study participants including history, examination findings, routine hospital investigations such as haematology, biochemistry blood tests, electrocardiogram & study imaging. This educational resource will include:

  • A series of 100 cases with a clinical diagnosis of type 2 myocardial infarction
  • All relevant clinical information on admission
  • Relevant coronary imaging (invasive coronary angiogram or CT coronary angiogram) & cardiac magnetic resonance (CMR) imaging studies
  • An interface which allows you to select & enlarge images
  • Case summaries which outline the adjudication panel's approach, once all available information was reviewed.

On 15 May 2021, we launched a pilot version of this educational resource using five (5) cases. These cases will include multiple choice questions (MCQs) as a guide & learning tool, as you work your way through each case.

We aim to populate the remainder of the educational resource before 31 Aug 2021. We will let those who register now, know as batches of new cases go live.

 

Participation

We have applied for CPD / CME recognition.

 

Approvals

The South East Scotland Regional Ethics Committee (17/SS/0078), ACCORD, & the Local NHS Health Board approved the DEMAND-MI study, in accordance with the Declaration of Helsinki.

 

Funding

The British Heart Foundation (FS/16/75/32533) funded the DEMAND-MI study.

https://clinicaltrials.gov/ct2/show/NCT03338504