Edinburgh Imaging

MSc projects 1011 003

The use of PET and MRI in Neurodegenerative Disease: The Irish experience

  • Background: Differentiation between atypical Parkinsonian syndromes and dementia subtypes is important but often difficult. We investigated the use of FDG- PET in differentiating between these diseases and the value of FDG- PET over MRI.
  • Methods: 36 patients with a diagnosis of atypical Parkinsonism (CBD, PSP, MSA and PPA) or dementia (AD, FTD, Vascular and DLBD) were included for FDG-PET analysis. 31 of those also had MRI and were included for MRI analysis.
  • Results: 22 of 36 patients had a FDG-PET scan supportive of a specific type of neurodegeneration. 2 of 31 patients had an MRI scan supportive of the underlying diagnosis. FDG- PET was a superior radiological tool in diagnosing specific neurodegeneration (p< 0.00004).
  • Conclusion: FDG- PET is useful in differentiating between different types of neurodegeneration. In our patient cohort it was significantly more useful than MRI. A large prospective study is warranted to confirm our results.
Project type:
  • Data acquisition & analysis
Imaging keywords:
Application / disease keywords:
  • Alzheimer's disease (AD)
  • Corticobasal degeneration (CBD)
  • Dementia
  • Frontotemporal dementia (FTD)
  • Multiple system atrophy (MSA)
  • Parkinsonism
  • Primary progressive aphasia (PPA)
  • Progressive supranuclear palsy (PSP)
  • Vascular dementia
  • Dr Nadine Dougall
  • 10-11