The use of PET and MRI in Neurodegenerative Disease: The Irish experience
| Abstract: |
- Background: Differentiation between atypical Parkinsonian syndromes and dementia subtypes is important but often difficult. We investigated the use of FDG- PET in differentiating between these diseases and the value of FDG- PET over MRI.
- Methods: 36 patients with a diagnosis of atypical Parkinsonism (CBD, PSP, MSA and PPA) or dementia (AD, FTD, Vascular and DLBD) were included for FDG-PET analysis. 31 of those also had MRI and were included for MRI analysis.
- Results: 22 of 36 patients had a FDG-PET scan supportive of a specific type of neurodegeneration. 2 of 31 patients had an MRI scan supportive of the underlying diagnosis. FDG- PET was a superior radiological tool in diagnosing specific neurodegeneration (p< 0.00004).
- Conclusion: FDG- PET is useful in differentiating between different types of neurodegeneration. In our patient cohort it was significantly more useful than MRI. A large prospective study is warranted to confirm our results.
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| Project type: |
- Data acquisition & analysis
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| Application / disease keywords: |
- Alzheimer's disease (AD)
- Corticobasal degeneration (CBD)
- Dementia
- Frontotemporal dementia (FTD)
- Multiple system atrophy (MSA)
- Parkinsonism
- Primary progressive aphasia (PPA)
- Progressive supranuclear palsy (PSP)
- Vascular dementia
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