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Flutemetamol MR PET study

ICH case-case comparison of Flutemetamol binding

This is an investigator-sponsored study, partly funded by GE Healthcare. The pathophysiological hypotheses to be tested are:

  • Primary: The amount and distribution of 18F-flutemetamol uptake will differ between cases with:

    • lobar ICH probably related to CAA, according to the modified Boston criteria9
    • lobar ICH possibly related to CAA, according to the modified Boston criteria9
    • deep ICH (neither probably or possibly related to CAA, according to the modified Boston criteria9)
  • Secondary:
    • To correlate the distribution of 18F-flutemetamol retention with magnetic resonance imaging (MRI) features associated with CAA (small foci of haemorrhage near the surface of the brain (lobar microbleeds) for example) and retinal imaging biomarkers.  
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