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Montagne Lab launches a new website

The Montagne Lab has launched a new website and Twitter.

The Montagne Lab has launched a new website and Twitter in April 2021.

Dr Axel Montagne

Axel Montagne completed his PhD at the University of Caen Normandy (France) with Professor Denis Vivien in 2012, followed by a postdoctoral training at the University of Southern California (USA) with Professor Berislav Zlokovic from 2013 to 2020. The University of Southern California already involved in the Perivascular Spaces in Small Vessel Diseases - an international project involving 8 researchcentres  of the Leducq Transatlantic Network of Research Excellence, led by The University of Edinburgh. In December 2020, Axel has joined the UK Dementia Research Institute at the University of Edinburgh, Centre for Clinical Brain Sciences as a Chancellor’s fellow and Group Leader.

He published several articles about the vascular contribution to dementia in humans but also using innovative animal models.


The Montagne Lab

The Montagne Lab is dedicated to uncover involvement of blood-brain barrier (BBB) dysfunctions in the early stages of brain disorders such as small vessel disease (SVD) and Alzheimer’s disease (AD). Dr Montagne's work combines molecular approaches with rodent non-invasive imaging, particularly MRI and PET, to study the causes and effects of blood-brain barrier (BBB) dysfunction in the context of neurodegenerative disease. BBB dysfunction is a major cause of inflammatory and bioenergetic deregulation in the brain, but the interplay between pericytes and endothelial cells that causes this collapse is not fully delineated. The Montagne lab is now focusing on probing BBB function and pericyte-endothelial cross-talk, especially the consequences of pericyte dysfunction on endothelial cells and the BBB, plus reciprocal signaling by activated endothelial cells.


My group aim to understand how, when, and where endothelial cells and pericytes lining the blood-brain barrier become dysfunctional in the early stages of age-related cognitive decline using cutting-edge brain imaging technology. Our ultimate goal is to develop precise treatments targeting brain vasculature to protect brain functions.

Dr Axel Montagne


The Montagne Lab website

Visit the Montagne Lab website:

Montagne Lab website

Follow Montagne Lab on Twitter

The Montagne Lab has also launched a Twitter account:

Montagne Lab on Twitter

Related links

Dr Axel Montagne publications (Edinburgh Research Explorer)

Dr Axel Montagne - UK DRI website (external link)

Perivascular Spaces in Small Vessel Disease website (external link)