Centre for Clinical Brain Sciences

Featured publications

CCBS Investigators publish >300 papers every year in Medline-indexed journals. Below is a small selection of publication highlights from the last three years.

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For a complete listing of CCBS publications, see the CCBS Research Outputs page on Edinburgh Research Explorer


Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project

Ritchie CW, Molinuevo JL, Truyen L, Satlin A, Van der Geyten S, Lovestone S; European Prevention of Alzheimer's Dementia (EPAD) Consortium. Lancet Psychiatry. 2016 Feb;3(2):179-86. doi: 10.1016/S2215-0366(15)00454-X. Epub 2015 Dec 10. Review. PubMed PMID: 26683239.

Hypothermia for Intracranial Hypertension after Traumatic Brain Injury

Andrews PJ, Sinclair HL, Rodriguez A, Harris BA, Battison CG, Rhodes JK, Murray GD; Eurotherm3235 Trial Collaborators. N Engl J Med. 2015 Dec 17;373(25):2403-12. doi: 10.1056/NEJMoa1507581. Epub 2015 Oct 7. PubMed PMID: 26444221.

This well conducted trial has shown that hypothermia can successfully reduce brain pressure following trauma, but after 6 months functional recovery was significantly worse than standard care alone

Professor Peter AndrewsHead of Critical Care Medicine, University of Edinburgh

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

Devlin AC, Burr K, Borooah S, Foster JD, Cleary EM, Geti I, Vallier L, Shaw CE, Chandran S, Miles GB. Nat Commun. 2015 Jan 12;6:5999. doi: 10.1038/ncomms6999. PubMed PMID: 25580746; PubMed Central PMCID: PMC4338554.

Short term exposure to air pollution and stroke: systematic review and meta-analysis

Shah AS, Lee KK, McAllister DA, Hunter A, Nair H, Whiteley W, Langrish JP,Newby DE, Mills NL. BMJ. 2015 Mar 24;350:h1295. doi: 10.1136/bmj.h1295. Review. PubMed PMID: 25810496; PubMed Central PMCID: PMC4373601.

Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial

IST-3 collaborative group. Wardlaw JM, Sandercock P, Cohen G, Farrall A, Lindley RI, von Kummer R, von Heijne A, Bradey N, Peeters A, Cala L, Adami A, Morris Z, Potter G, Murray G, Whiteley W, Perry D, Sakka E. Lancet Neurol. 2015 May;14(5):485-96. doi: 10.1016/S1474-4422(15)00012-5. Epub 2015 Mar 27. PMID: 25819484.


Outcome after conservative management or intervention for unruptured brain arteriovenous malformations

Al-Shahi Salman R, White PM, Counsell CE, du Plessis J, van Beijnum J, Josephson CB, Wilkinson T, Wedderburn CJ, Chandy, Z, St. George EJ, Sellar RJ, Warlow CP; for the Scottish Audit of Intracranial Vascular Malformations Collaborators. JAMA. 2014 Apr 23-30;311(16):1661-9. doi: 10.1001/jama.2014.3200. PubMed PMID: 24756516.

For most people whose AVM has not caused a bleed, the risks of treatment exceed the benefits.

Professor Rustam Al-Shahi Salman

De novo mutations in schizophrenia implicate synaptic networks

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC. Nature. 2014 Feb 13;506(7487):179-84. doi: 10.1038/nature12929. Epub 2014 Jan 22. PMID: 24463507.

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP. Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations. Neuron. 2014 Feb 5;81(3):536-43. doi: 10.1016/j.neuron.2013.12.018. PMID: 24507191.


Brain banking for neurological disorders

Samarasekera N, Al-Shahi Salman R, Huitinga I, Klioueva N, McLean CA, Kretzschmar H, Smith C, Ironside JW. Lancet Neurol. 2013 Nov;12(11):1096-105. doi: 10.1016/S1474-4422(13)70202-3. Epub 2013 Sep 25. Review. PMID: 24074724.

Selective serotonin reuptake inhibitors for stroke recovery

Mead GE, Hsieh CF, Hackett M. JAMA. 2013 Sep 11;310(10):1066-7. doi: 10.1001/jama.2013.107828. PMID: 24026602.

Prediction of depression in individuals at high familial risk of mood disorders using functional magnetic resonance imaging

Whalley HC, Sussmann JE, Romaniuk L, Stewart T, Papmeyer M, Sprooten E, Hackett S, Hall J, Lawrie SM, McIntosh AM. PLoS One. 2013;8(3):e57357. doi: 10.1371/journal.pone.0057357. Epub 2013 Mar 6. PMID: 23483904.

Synaptic scaffold evolution generated components of vertebrate cognitive complexity

Nithianantharajah J, Komiyama NH, McKechanie A, Johnstone M, Blackwood DH, St Clair D, Emes RD, van de Lagemaat LN, Saksida LM, Bussey TJ, Grant SG. Nat Neurosci. 2013 Jan;16(1):16-24. doi: 10.1038/nn.3276. Epub 2012 Dec 2. PMID: 23201973.

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura AL, Carrasco MA, Phatnani HP, Shum C, Wilmut I, Maniatis T, Shaw CE, Finkbeiner S, Chandran S. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4697-702. doi: 10.1073/pnas.1300398110. Epub 2013 Feb 11. PMID: 23401527.


Using patient stem cells to model MND in a dish offers untold possibilities for how we study the cause of this terrible disease as well as accelerating drug discovery by providing a cost-effective way to test many thousands of potential treatments.

Professor Siddharthan Chandran