Centre for Clinical Brain Sciences

Professor Seth Grant

Professor Seth Grant directs the Genes2Cognition programme, investigating the molecular basis of synaptic biology and disease.

Professor Seth Grant

Professor of Molecular Neuroscience

  • G2C::Genes to Cognition
  • Centre for Clinical Brain Sciences

Contact details


  • 1984, Graduated from Sydney University with a Bachelor of Science (Medicine) in Physiology, Bachelor of Medicine and Bachelor of Surgery
  • 1985-1989, Postdoctoral Fellow at Cold Spring Harbor Laboratory with Douglas Hanahan
  • 1989-1994, Postdoctoral Fellow with Eric Kandel at Columbia University
  • 1994, Centre for Genome Research at Edinburgh University
  • 2000, Professor of Molecular Neuroscience, Edinburgh University
  • 2003, Principal Investigator at the Wellcome Trust Sanger Institute in Cambridge
  • 2011, Professor of Molecular Neuroscience , University of Edinburgh
  • Additional appointments: John Cade Visiting Professor at Melbourne University, Honorary Professorship at Cambridge University and elected Fellow of the Royal Society of Edinburgh

Research summary

The long-term aim is to understand the fundamental mechanisms of behaviour and how these mechanisms are involved in brain disease.

The research has focussed on the study of genes and proteins that control the synapses between nerve cells. Multiprotein machines comprising many different protein components are responsible for basic innate and learned behaviours and dysfunction in many brain diseases.

Recent work shows that these mechanisms are conserved between mice and humans opening new avenues for diagnosis and therapeutic discoveries. The Genes to Cognition programme has generated a large amount of data and tools that are freely available (see below).

overview of synaptic function

Research aims and areas of interest

Research group members

  • Vlad Anton : PhD Student
  • Rand Dahan: Research Technician
  • Ragini Gokhale: Informatics Engineer
  • Yoo Koung Ko : PhD Student
  • Noboru Komiyama : Senior Lecturer
  • Dimitra Koukaroundi : Research Technician
  • Sarah Lempriere : PhD Student
  • Cathy McLaughlin : Lab Manager
  • Zhen (Ricky) Qiu : Image Analysis Developer
  • Laura Tomas Roca : Postdoctoral Fellow
  • Malikmohamed Yousuf: Postdoctoral Fellow

Sources of funding

The Grant lab is currently funded by The Wellcome Trust, Medical Research Council and European Union (GENCODYS, EUROSPIN, SYNSYS, Human Brain Project).