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Brain study sheds light on epilepsy seizures

Nov 2015: A study of how brain cells communicate with each other when minds are most active could aid research into epilepsy.

Researchers have identified a key molecule - called VAMP4 - that is required for neurons to send messages to each other during bursts of brain activity.

The Edinburgh team now plans to investigate whether altering VAMP4 levels can help to switch off excess brain activity and calm the symptoms of epileptic seizures.

They say the findings could eventually lead to new medicines that help patients with epilepsy who do not respond to existing treatments.

Neuron activity

Seizures are caused by abnormal electrical signalling in the brain that is prompted by an excess of communication between neurons.

Scientists focused on a specific process called activity-dependent bulk endocytosis (ABDE), which enables neurons to continue communicating during bursts of brain activity.

They found that VAMP4 is essential for ADBE but not required for other processes that are routinely involved in communication between neurons.

This means that medicines designed to target VAMP4 could have fewer side effects for normal day-to-day brain function than existing epilepsy treatments.

Future studies

Because ABDE is also involved in other brain functions - such as creating new memories - further research is needed to understand what the effects of manipulating VAMP4 might be, the researchers say.

The study is published in the journal Neuron. It was funded by the Medical Research Council.

This research is still in very early stages but it gives us a new avenue to explore for new epilepsy treatments, which are urgently needed. Around one third of children with epilepsy cannot control their seizures with the treatments that are currently available.

Professor Mike CousinMuir Maxwell Epilepsy Centre, University of Edinburgh

Related Links

Muir Maxwell Epilepsy Centre

CCBS research into neurdevelopmental conditions

Dr Richard Chin (Director of Muir Maxwell Centre) Principal Investigator profile