MRC Centre for Reproductive Health
MRC Logo JAN 2019

Professor Hilary O D Critchley

Research interests, current research projects and current clinical trials.

 

Professor Hilary OD Critchley

MBChB, MD, DSc, FRCOG, FMedSci, FRSE

  • Head, Deanery of Clinical Sciences, Edinburgh Medical School
  • Professor of Reproductive Medicine and; Co-Deputy Director MRC Centre for Reproductive Health
  • Consultant Gynaecologist, NHS Lothian

Contact details

Address

Street

The Queen's Medical Research Institute
Edinburgh BioQuarter
47 Little France Crescent

City
Edinburgh
Post Code
EH16 4TJ

Availability

Research interests

Our research specifically examines local mechanisms within the womb-lining (endometrium) involved in menstruation and abnormal uterine bleeding (AUB). Menstruation displays features of an inflammatory event and is a physiological event of repeated "tissue injury and repair" We study the cascade of events that occur in cells of the endometrium and that lead to its shedding. These events are triggered by withdrawal of the hormone, progesterone (P). This occurs at the end of each monthly cycle prior to a period. We are interested in the complex dialogue between circulating steroid hormones and the many different cell types, including immune cells that constitute the endometrium.

We also study factors that switch on production of molecules involved in blood vessel growth and repair in the endometrium; both necessary events to prepare for the next menstrual cycle. If we can understand how the womb heals itself without scarring as women go through their menstrual cycles we hope we will contribute valuable information relevant to inflammation and scarring throughout the body. If these events are disturbed then abnormal menstrual bleeding may be the result. We are therefore studying endometrial samples collected from women attending with menstrual complaints including women with fibroids. We hope that information about the molecular and cellular pathways involved in menstruation will help identify new targets for treatment, especially if these treatments could be delivered directly to the uterus.

Development of novel medical treatments for management of debilitating menstrual complaints aims to enable women to avoid surgery and thereby preserve uterine function and fertility potential.

 

Some Publications:

  • Critchley, H. O. ., Babayev, E., Bulun, S. E., Clark, S., Garcia-Grau, I., Gregersen, P. K., Kilcoyne, A., Kim, J.-Y. J., Lavender, M., Marsh, E. E., Matteson, K. A., Maybin, J. A., Metz, C. N., Moreno, I., Silk, K., Sommer, M., Simon, C., Tariyal, R., Taylor, H. S., Griffith, L. G. (2020). ‘Menstruation: science and society’. American Journal of Obstetrics and Gynecology, 223(5), 624–664. PMID: 32707266   DOI: 10.1016/j.ajog.2020.06.004. Epub 2020 Jul 21
  • Critchley, H. O. D., Maybin, J. A., Armstrong, G. M., & Williams, A. R. W. (2020). ‘Physiology of the endometrium and regulation of menstruation’. Physiological Reviews, 100(3), 1149–1179. PMID: 32031903   DOI: 10.1152/physrev.00031.2019
  • Warner, P., Whitaker, L. H. R., Parker, R. A., Weir, C. J., Douglas, A., Hansen, C. H., Madhra, M., Hillier, S. G., Saunders, P. T. K., Iredale, J. P., Semple, S., Slayden, O. D., Walker, B. R., & Critchley, H. O. D. (2021). ‘Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM).’ EBioMedicine, 69, 103434–103434. PMID: 34218053   DOI: 10.1016/j.ebiom.2021.103434
  • Chodankar, R. R., Murray, A., Nicol, M., Whitaker, L. H. R., Williams, A. R. W., & Critchley, H. O. D. (2021). ‘The endometrial response to modulation of ligand-progesterone receptor pathways is reversible’. Fertility and Sterility, S0015-0282(21)00125-4. PMID: 33865567   DOI: 10.1016/j.fertnstert.2021.02.008
  • Al-Hendy, A., Lukes, A. S., Poindexter, A. N., Venturella, R., Villarroel, C., Critchley, H. O. ., Li, Y., McKain, L., Arjona Ferreira, J. C., Langenberg, A. G. ., Wagman, R. B., & Stewart, E. A. (2021). ‘Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy’. The New England Journal of Medicine, 384(7), 630–642. PMID: 33596357   DOI: 10.1056/NEJMoa2008283
  • Munro, M. G., Critchley, H. O. ., Fraser, I. S., Haththotuwa, R., Kriplani, A., Bahamondes, L., Füchtner, C., Tonye, R., Archer, D., Abbott, J., Abdel‐Wahed, A., Berbic, M., Brache, V., Breitkoph, D., Brill, A., Broder, M., Brosens, I., Chwalisz, K., Clark, J., Farquhar, C. (2018). ‘The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions’. International Journal of Gynaecology and Obstetrics, 143(3), 393–408. PMID: 30198563   DOI: 10.1002/ijgo.12666
  • Maybin, J. A., Murray, A. A., Saunders, P., Hirani, N., Carmeliet, P., & Critchley, H. (2018). ‘Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation’. Nature communications, 9(1), 295.  PMID: 29362355   DOI: 10.1038/s41467-017-02375-6

Full list of publications:

pubmed

research explorer

Current research projects:

  • Determining the endometrial phenotype of women with abnormal uterine bleeding (AUB).
  • Unravelling the causes of declining uterine function with age
  • Mechanisms of action selective progesterone receptor modulators (SPRMs) on the endometrium and uterus.
  • Novel magnetic resonance imaging (MRI) of uterine morphology in women with AUB.

Recent clinical studies:

  • DexFEM (MRC DCS/ DPFS funding)

Low dose dexamethasone as treatment for women with heavy menstrual bleeding: A response-adaptive randomised placebo-controlled dose-finding parallel group trial Dexamethasone for Excessive Menstruation (DexFEM).  

  • UCON (NIHR/MRC EME programme funding)

Staff/group members:

  • Catherine Murray
  • Alison Murray
  • Moira Nicol
  • Barbara Hamilton

PhD/MD Students:

  • Rohan Chodankar
  • Varsha Jain
  • Aleks Tsolova

Principal collaborators

Local:

  • Professor Neil Carragher
  • Dr Ooi Thye Chong
  • Dr Douglas Gibson
  • Professor Andrew Horne
  • Dr Lucy Kershaw
  • Dr Jackie Maybin
  • Professor Jeff Pollard
  • Professor Neil Roberts
  • Professor Philippa Saunders
  • Dr Scott Semple
  • Dr Pamela Warner
  • Professor Chris Weir
  • Dr Lucy Whitaker
  • Emeritus Professor Alistair Williams

National:

  • Professor Siladitya Bhattacharya (Aberdeen)
  • Professor Justin Clark (Birmingham)
  • Professor Dharani Hapangama (Liverpool)
  • Professor Gavin Kelsey (Babraham Institute, Cambridge)
  • Professor Mary Ann Lumsden (Glasgow)
  • Professor Ashley Moffett (Cambridge)
  • Dr Margherita Turco (Cambridge)
  • Professor Brian Walker (Newcastle)

International:

  • Professor Ian Fraser (Sydney, Australia)
  • Professor Linda Griffith (Massachusetts Institute of Technology, USA)
  • Professor Sun-Wei Guo, Fudan University, Shanghai, China
  • Professor Myriam Hemberger and Professor Wendy Dean (Calgary, Canada and Babraham Institute, Cambridge UK)
  • Professor Doug Lauffenburger (Massachusetts Institute of Technology, USA)
  • Professor Mac Munro (Los Angeles, USA)Professor Felice Petraglia (Florence, Italy)
  • Professor Peter Rogers (Melbourne, Australia)
  • Professor Carlos Simon (Valencia, Spain)
  • Dr Ov Slayden (Portland, USA)
  • Dr Steve Yellon (Loma Linda University, USA)

Current responsibilities include:

  • Incoming Chair: International Federation of Gynecology and Obstetrics (FIGO) Menstrual Disorders Committee (MDC)
  • Centre for Trophoblast Research (CTR), Cambridge –  Chair CTR Scientific Advisory Board
  • Society for Endometriosis and Uterine Disorders (SEUD) Abnormal Uterine Bleeding (AUB) Task Force (Chair)
  • World Endometriosis Society (WES) Ambassador (from 2018)

Current Editorial Board Membership:

Journal of Reproductive Immunology

Reproductive Sciences

Journal of Endometriosis and Pelvic Pain Disorders

F1000 Research / co-Head of Faculty for Women’s Health

Physiological Reviews (from April 2019)

 

Awards:

2021: Professor Critchley recipient of the Society for Reproductive Investigation (SRI) DeCherney Society Lifetime Distinguished Service Award: recognises an individual who has made outstanding contributions to the Society for Reproductive Investigation and significant contributions to the field of reproductive medicine and women's health.

2021: Professor Critchley recipient of RCOG Annual Academic Award. This prize has been awarded by the RCOG in recognition of her distinguished service to academic obstetrics and gynaecology, in particular her outstanding contributions to scientific discovery, pre-clinical and clinical research, academic education and training.

2020: The SRF (Society for Reproduction and Fertility) Distinguished Scientist Anne McLaren Award 2020 has been awarded to Professor Hilary O D Critchley, MRC Centre for Reproductive Health, The University of Edinburgh, for her outstanding contributions in the field of women's reproductive biology.

2019: Featured in Celebrating Women in Science in Scotland Exhibition, Royal Society of Edinburgh – an “exhibition celebrating some of Scotland's finest female scientists”. https://www.rse.org.uk/women-science-exhibition/

2019: Exemplar of international recognition: NIH, Bethesda, USA: (UK invited participant) meeting: Menstruation, Science and Society (goal to discuss promising new discoveries and avenues of research surrounding menstruation).

2017 University of Edinburgh awarded Queen's Anniversary Prize for "Clinical innovations to respond to major unmet needs in women's health" submitted on behalf of the University of Edinburgh by JE Norman and HOD Critchley

2014 Awarded Lady Margaret MacLellan Award, Tenovus Scotland for contributions to 'Women's Health'.

 

Video: