MRC Centre for Reproductive Health
MRC Logo JAN 2019

Professor Andrew Horne

Research interests and grants.

Professor Andrew W Horne (MB ChB, PhD, FRCOG, FRCP Edin)

Professor of Gynaecology and Reproductive Sciences.

  • Chair of Academic Board, Royal College of Obstetricians and Gynaecologists
  • Co-Director EXPPECT Centre for Pelvic Pain and Endometriosis
  • Affiliate Member, Usher Institute

Contact details

Address

Street

The Queen’s Medical Research Institute
Edinburgh BioQuarter
47 Little France Crescent

City
Edinburgh
Post Code
EH16 4TJ

Clinical matters

Please note that, due to NHS Lothian IT Security Policy, I am afraid that I am unable to respond to emails about clinical matters. If you would like me to contact you about a clinical matter, please email Fiona Elliot (my NHS secretary on +44(0)131 242 2525), and include your phone number (and/or address), so that I can get back to you.

Research Interests

  • Pelvic pain and endometriosis (EXPPECT Edinburgh)

Visit the EXPPECT Edinburgh website

  • Ectopic pregnancy

Grants

  • Chief Scientist Office 2019-2020 (£201,867) “ESPriT: The effectiveness of laparoscopic treatment of isolated superficial peritoneal endometriosis for managing chronic pelvic pain in women: a randomised controlled feasibility trial” AW Horne (CI), J Norrie, K Cooper, J Daniels, E Cox, L Hummelshoj

  • MRC (£738,262) 2018-21 "Identifying disease promoting macrophages and tissue-identity in endometriosis” E Greaves (CI), AW Horne, PTK Saunders, S Jenkins

  • MRC CiC Grant (£120,172) 2018-19 "EPiC: Phase II single-arm open label clinical trial to evaluate the efficacy and side effects of dichloroacetate to treat endometriosis-associated pain” AW Horne (CI), PTK Saunders, J Daniels

  • Wellbeing of Women (£197,039) 2018-21 "EXPEDITE: metabolomics and cytokine profile analysis in biofluids to develop a non-invasive diagnostic test for ectopic pregnancy" D Hapangama (CI), L-Y Lian, K Gemzell-Danielsson, PG Lalitkumar, M Phelan, AW Horne

  • NIHR (£165,595) 2018-19 "CRESCENDO: Creating a Clinical Prediction Model to predict Surgical Success in Endometriosis” E Ball (CI), N Marlin, C Rivas, AW Horne, J Allotey, J Dodds, E Cox

  • Ferring Research Innovation Grant ($70,000) 2017-­18 “Targeting TGFß-­1 with an extracellular peptide inhibitor to treat women with peritoneal endometriosis” AW Horne (CI), PTK Saunders, SF Ahmad

  • HTA 2017-2019 (£1,800,000) MifeMiso: A randomised placebo-controlled trial of mifepristone and misoprostol versus misoprostol alone in the medical management of missed miscarriage. A Coomarasamy (CI), AW Horne, H Williams, J Chu, J Daniels, L Middleton, L Jones, T Roberts, I Goranitis, M Shehmar, M Choudhary, K Hinshaw, J Ross, D Jurkovic, L Watkins, J Walker, P Gupta, R Small, F Izzat, I Granne, Y Cheong, S Quenby, S Thangaratinam, J Thorton

  • Wellbeing of Women (2016-18) £198,864 Novel repurposing of anticancer drugs to treat endometriosis. AW Horne (CI), PTK Saunders, P Fowler, C Becker, D Hapangama, K Zondervan, S Sundar, MC Jones, E Greaves

  • MRC (2016-18) £302,097 CB2 agonists as a novel treatment for women with endometriosis-associated pain. PTK Saunders (CI), AW Horne, E Greaves

  • MRC Programme Grant (£1,450,704) 2016-21 “Androgens and women’s health: developing new therapies to treat endometrial disorders” PTK Saunders (CI), AW Horne, HOD Critchley, DA Gibson

  • EME (£999,811) 2016-20 “GEM3: A multi-centre double-blind placebo-controlled randomised trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy” AW Horne (CI), S Tong, WC Duncan, B Mol, S Bhattacharya, J Daniels, A Coomaraswamy, D Jurkovic, T Bourne, C Bottomley, A Peace-Gadsby

  • Wellcome Trust (£237,55) 2015-2018 Clinical Research Training Fellowship [Campbell] AW Horne, N Gray

  • EME (£1,208,722) 2015-19 “GaPP2: A randomised controlled trial of the efficacy and mechanism of action of gabapentin for the management of chronic pelvic pain in women” AW Horne (CI), K Vincent, J Daniels, L Middleton, G Macfarlane, Y Cheong, A Baranowski, A Williams, J Birch, S Bhattacharya

  • HTA (£1,962,989) 2015-19 “PRISM: Effectiveness of progesterone to prevent miscarriage in women with early pregnancy bleeding: A placebo-controlled randomised trial” A Coomaraswamy (CI), AW Horne, C Overton, C Bottomley, W Duncan, D Jurkovic,D Feroza, H Harb, J Daniels, J Norman, K Hinshaw, L Middleton, MA Lumsden, N Raine-Fenning, R Farquharson, R Bender-Atik, S Quenby, T Bourne, T Roberts

  • HTA (£2,487,834) 2013-19 “PRE-EMPT: Preventing Recurrence of Endometriosis by Means of long acting Protestogen Therapy” S Bhattacharya (CI), K Cooper, J Gupta, J Daniels, J Clark, E Denny, E Saridogan, L Middleton, G Jones, AW Horne, C Becker

Reactions in the media

Staff/group members

  • Mrs Ann Doust (Research Portfolio Manager)
  • Dr Magdalena Koscielniak (Clinical Trials Manager)
  • Dr Furquan Ahmad (Post-Doctoral Scientist)
  • Mrs Helen Dewart (Senior Clinical Research Nurse)
  • Mrs Nicola Watson (Research Nurse)
  • Ms Priscilla Fernandez (Research Midwife)
  • Ms Lauren Sutherland (Research Assistant)
  • Ms Ashleigh Symington (Research Assistant)
  • Mr Jordan Doust (Research Administrator)
  • Ms Heather Flannigan (PhD Student)
  • Ms Chloe Hogg (PhD Student)
  • Ms Jackie Young (PA)

 

Andrew Horne Staff members

 

View the Endocrinology website

Principal collaborators

University of Edinburgh:

  • Hilary Critchley (CRH)
  • Colin Duncan (CRH)
  • Philippa Saunders (CIR)
  • Dr Erin Greaves (CRH)
  • Sarah Howie (CIR)
  • Gary Entrican (Moredun Research Institute)

National/international:

  • Siladitya Bhattacharya (Aberdeen University)
  • Katy Vincent (University of Oxford)
  • Jane Daniels (University of Nottingham)
  • Stephen Tong (University of Monash Melbourne)
  • Kevin Cooper (University of Aberdeen)
  • Ferring, Astra Zeneca, Roche, Nordic Pharma

Responsibilities

  • Chair of Academic Board, RCOG
  • Co-Director EXPPECT Centre for Pelvic Pain and Endometriosis
  • Past Chair of ESHRE Special Interest Group Endometriosis/Endometrium
  • Lead of James Lind Alliance Priority Setting Partnership for Endometriosis
  • Academic Representative for the RCOG Scottish Committee
  • Member of NICE Endometriosis Guideline Group
  • Past member of the ESHRE Endometriosis Guideline Group
  • Member of Wellbeing of Women Research Advisory Committee
  • Trustee and Medical Advisor to the Ectopic Pregnancy Trust
  • Medical Advisor to Endometriosis UK
  • Medical Advisor to Pelvic Pain Support Network
  • Deputy Editor of Human Reproduction Open
  • Member of RCOG Early Pregnancy Clinical Studies Group
  • Member of the Blair Bell Committee
  • UK ESHRE Representative

Book chapters

  1. Che Bakri NA, Busby-Earle C, Steel R, Horne AW. ‘Pelvic and Reproductive System Symptoms’ In ABC of Medically Unexplained Symptoms. Ed Burton. Wiley-Blackwell 2013 ISBN: 978-1-119-96725-5.
  2. Svingalam V, Wilson J, Horne AW. ‘Novel pain relief agents in endometriosis’ In World Clinics Obstetrics and Gynaecology. Eds Bhattacharya, Arora. Jaypee Brothers Medical Publishers (P) Ltd (in press).
  3. Horne AW, Critchley HOD. ‘Medical Therapies for Pain – Progestins’ In Endometriosis: Science and Practice. Eds Giudice, Evers, Healy. Wiley-Blackwell 2012 ISBN: 978-1-4443-3213-1.
  4. Horne AW, Critchley HOD. ‘Menstrual Disorders’. In Dewhurst’s 8th Edition. Ed Edmonds. Wiley-Blackwell 2012 ISBN: 978-0-470-65457-6.
  5. Horne AW, Ford CM. ‘The normal menstrual cycle’ and Horne AW, ‘Disorders of the menstrual cycle’. In Gynaecology by Ten Teachers, 19th Edition. Hodder Arnold Health Sciences 2011 ISBN: 978-0-340-983-546.
  6. Munro KI, Horne AW, Critchley HOD. Amenorrhoea, oligomenorrhoea and hypogonadal-pituitary function. In Gynaecology, 4th Edition. Eds Shaw, Luesly, Monga. Churchill Livingston 2010 ISBN: 978-0-7020-3120-5.
  7. Maybin J, Horne AW, Critchley HOD. ‘Menstrual Disorders’ and ‘Benign Gynaecological Disorders’. In Training in Obstetrics and Gynaecology; the essential curriculum, 1st Edition. Eds Sarris, Saxena, Bewley. Oxford University Press 2009 ISBN 978-0-19-921847-9.
  8. Horne AW. ‘Implantation and early pregnancy’. In Gynaecology by Ten Teachers, 20th Edition. CRC Press 2017 ISBN: 978-1-4987-4428-7.
  9. Campbell LL, Horne AW (2018). Ectopic and Heterotopic Pregnancies. In M. K. Skinner (Ed) Encyclopedia of Reproduction. Vol 5 pp 311–316. Academic Press: Elsevier 2018 ISBN: 9780128118993.