MRC Centre for Reproductive Health
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Professor Andrew Horne

Research interests and grants.

Professor Andrew W Horne (PhD, FRCOG, FRCP Edin, FRCSEd, FRSE)

Professor of Gynaecology and Reproductive Sciences

  • Honorary Consultant Gynaecologist
  • Co-Director EXPPECT Centre for Pelvic Pain and Endometriosis
  • Fellow of the Royal Society of Edinburgh

Contact details

Address

Street

The Queen’s Medical Research Institute
Edinburgh BioQuarter
47 Little France Crescent

City
Edinburgh
Post Code
EH16 4TJ

Clinical matters

Please note that, due to NHS Lothian IT Security Policy, I am afraid that I am unable to respond to emails about clinical matters. If you would like me to contact you about a clinical matter, please email Fiona Elliot (my NHS secretary on +44(0)131 242 2525), and include your phone number (and/or address), so that I can get back to you.

Research Interests

  • Leader of an interdisciplinary research team, that includes clinicians and discovery scientists, investigating pelvic pain, endometriosis and early pregnancy disorders.
  • Founder and Co-Director of the EXPPECT Centre for Endometriosis and Pelvic Pain in Edinburgh. EXPPECT brings together individuals involved in the clinical care of women with pelvic pain and endometriosis with discovery scientists, to form a hub within which innovative approaches to pelvic pain treatment can be developed in collaboration with commercial partners.

Current research projects

Exppect Edinburgh

GEM3

ESPriT2

Finding Endometriosis using Machine Learning

Endo1000

Staff / group members

Exxpect team

Dr Lucy Whitaker (Clinical Lecturer in Obstetrics and Gynaecology)

Mrs Ann Doust (Research Portfolio Manager)

Mrs Frances Collins (Clinical Trial / Laboratory Manager)

Dr Firat Buyuktaskin (Postdoctoral Fellow)

Ms Lauren Sutherland (Trial Coordinator))

Mrs Nicola Watson (Research Nurse)

Ms Priscilla Fernandez (Research Midwife)

Mrs Jane Hellewell (Research Nurse)

Mrs Sharon McPherson (Research Nurse)

Ms Cathy Wells (Research Assistant)

Mr Jordan Doust (Data Manager)

Ms Sam White (Research Administrator)

Current PhD/MD students

Ms Heather Flannigan (PhD Student)

Ms Francesca Hearn-Yeates (PhD Student)

Ms Katherine Edgley (PhD Student)

Mr Dolapo Ayansina (PhD Student) (University of Aberdeen)

Current and recent grants

EU Horizon 2020 2021-2024 (€5,900,000) “Finding endometriosis using machine learning” co-PI

UKRI (£4,100,000) 2021-2025 “MICA: ADVANTAGE visceral pain consortium: Advanced Discovery of Visceral Analgesics via Neuroimmune Targets and the Genetics of Extreme human phenotype” Woods G (CI), Horne AW, Lee M, Malliaris G, St John Smith E, Andersson D, Denk F, Williams A, Tsanas T, Saunders P

NIHR HTA (£1,728,286) 2020-2025 “Deep infiltrating endometriosis: management by medical treatment versus early surgery: DIAMOND” Clark TJ (CI), Cooper K (co-CI), Bhattacharya S, Byrne D, Smith P, Horne AW, Amer S, Maclennan G, Scotland G, Murchie P, Gillies K, Gamaleldin I, Vashisht A, Cox E

NIHR HTA (£2,057,700) 2020-25 “ESPriT2: A multi-centre randomised controlled trial to determine the effectiveness of laparoscopic treatment of isolated superficial peritoneal endometriosis for the management of chronic pelvic pain in women” Horne AW (CI), Whitaker L (co-CI), Norrie J, Daniels J, Stephens J, Cooper K, Clark TJ, Becker C, Cheong Y, Thornton J, Maheshwari A, Vincent K, Jackson L, Cox, E, Hummelshoj L, King K

HTA 2020-25 £1,660,141 “Recurrence of Endometriosis: a randomised controlled trial of clinical and cost-effectiveness of Gonadotrophin Releasing Hormone Analogues with add-back hormone replacement therapy versus repeat Laparoscopic surgery (REGAL trial)” Saraswat L (CI), Cooper K, Bhattacharya S, Horne AW, Clark TJ, Becker C, Vyas S, Saridogan E, McLennan G, Scotland G, Gillies K, Jones G.

Selected recent publications

Saunders PTK, Horne AW. Endometriosis: etiology, pathobiology, and therapeutic prospects. Cell 2021 184(11):2807-2824.

Hogg C, Panir K, Dhami P, Rosser M, Mack M, Soong D, Pollard JW, Jenkins SJ, Horne AW, Greaves E. Macrophages inhibit and enhance endometriosis depending on their origin. Proc Natl Acad Sci USA 2021 118(6):e2013776118.

Horne AW, Vincent K, Hewitt CA, Middleton LJ, Koscielniak M, Szubert W, Doust AM, Daniels JP, on behalf of the GaPP2 collaborative. Randomised controlled trial of gabapentin for chronic pelvic pain in women. Lancet 2020 396(10255):909-917. Awarded European Society of Regional Anaesthesia and Pain Therapy ‘Best Chronic Pain Paper Award 2021’.

Chu JJ, …. Horne AW, Quenby S, Coomarasamy A. Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial. Lancet 2020 S0140-6736(20)31788-8.

Horne AW, Saunders PTK. Endometriosis. Cell 2019 179(7):1677-1677e1.

Horne AW, Ahmad SF, Carter R, Simitsidellis I, Greaves E, Hogg C, Morton NM, Saunders PTK. Repurposing dichloroacetate for the treatment of women with endometriosis. Proc Natl Acad Sci USA 2019 116(51):25389-25391.

Coomarasamy A, Devall AJ, …., Horne A, Jurkovic D. A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy. N Engl J Med 2019 380(19):1815-1824.

Horne AW, Vincent K, Cregg R, Daniels J. Is gabapentin effective for women with unexplained chronic pelvic pain? BMJ 2017 358:j3520.

Kvaskoff M, Horne AW, Missmer SA. Informing women with endometriosis about ovarian cancer risk. Lancet 2017 390(10111):2433-2434.

Horne AW, Saunders PTK, Abokhrais IM, Hogg L; Endometriosis Priority Setting Partnership Steering Group. Top ten endometriosis research priorities in the UK and Ireland. Lancet 2017 389(10085):2191-2192.

Media

Endometriosis: How wearable technology could improve limited treatment options for this painful condition

The way endometriosis is diagnosed is (finally) changing - but why has it taken so long?

A common treatment for endometriosis could actually be making things worse

I fear my period coming every month

Recent awards

Tam Dalyell Prize for Excellence for Engaging the Public with Science (2022)

Fellowship Ad Hominum of the Royal College of Surgeons of Edinburgh (FRCSEd) (2021)

Fellowship of the Royal Society of Edinburgh (FRSE) (2021)

Fellowship of the Faculty of Pain Medicine of the Royal College of Anaesthetists (2019)

Fellowship of the Royal College of Physicians of Edinburgh (FRCP Edin) (2018)

Current external activities

Specialty Advisor to the Chief Medical Officer for Obstetrics and Gynaecology at the Scottish Government

Co-Editor in-chief of Reproduction and Fertility (RAF)

Member of Efficacy and Mechanism Evaluation Programme (EME) Funding Committee

Scientific Board Member of the World Endometriosis Society (WES)

Scientific Board Member of the Society of Endometriosis and Uterine Disorders (SEUD)

Scientific Board Member Association of Early Pregnancy Units (AEPU)

Medical Advisor and Trustee to Endometriosis UK

Medical Advisor and Trustee to the Ectopic Pregnancy Trust

Medical Advisor to the Pelvic Pain Support Network

Principal Collaborators

Professor Philippa Saunders, University of Edinburgh

Dr Lucy Whitaker, University of Edinburgh

Dr Thanasis Tsanas, University of Edinburgh

Professor Colin Duncan, University of Edinburgh

Professor Norah Spears, University of Edinburgh

Professor Geoff Woods, University of Cambridge

Dr Mike Lee, University of Cambridge

Professor Katy Vincent, University of Oxford

Professor Krina Zondervan, University of Oxford

Professor Christian Becker, University of Oxford

Dr Erin Greaves, University of Warwick

Dr Lucky Saraswat, University of Aberdeen

Professor Jane Daniels, University of Nottingham

Dr Ulrik Bak, University of Aarhus

Dr Dorte Rytter, University of Aarhus

Professor Stephen Tong, University of Melbourne

Professor Ben Mol, University of Adelaide

Professor Stacey Missmer, University of Michigan

Edinburgh and Birmingham Clinical Trial Units