HOPE

Take part in a study

The studies below are currently recruiting with the aim of improving the lives of those who menstruate.

The IMAGEN study (The impact of androgens on endometrial health)

WHY is it being done? The aim of this study is to determine the impact of androgen medications on the lining of the womb (e.g. in those undergoing gender reassignment).

WHAT is involved? This study is recruiting people who are having a hysterectomy who are taking androgens and those who are not (controls). Participants will be asked to provide a blood sample and a sample of the womb at the time of their hysterectomy. It does not alter the surgical procedure.

WHERE is this study taking place? NHS Lothian

WHO can take part? Those who

  • are aged 18-55
  • are having a hysterectomy
  • are currently taking androgen therapy OR have not taken any hormone treatments in the last 2 months

Contact details

Dr Jackie Maybin Jackie.maybin@ed.ac.uk

UCON Study Logo

UCON (Ulipristal acetate versus conventional management of heavy menstrual bleeding (HMB; including uterine fibroids): a randomised controlled trial and exploration of mechanism of action).

WHY is it being done? The study aims to determine if Ulipristal acetate (UPA) is more effective at reducing heavy menstrual bleeding than LNG-IUS (hormone intrauterine system) after 12 months of treatment.

WHAT is involved? Women will be asked to read an information leaflet about the study and will be given the opportunity to ask questions regarding the study. Should they wish to take part, they will be asked to provide written informed consent. They will then complete a questionnaire, a menstrual blood loss diary, ultrasound scan, an endometrial biopsy and blood tests. Women will be assigned to having a intrauterine device inserted or be given UPA tablets.

For LNG-IUS: women will have a coil fitted with the hospital or GP. They will be asked to complete a questionnaire/blood loss diary at 3, 6 and 12 months post-insertion. After 12 months, women will receive an ultrasound and be asked for a blood sample.

For UPA: women will be require to take UPA tablets every day for weeks 1-12. There will be no tablets between weeks 13-16. Treatment will commence again in this same 16 week cycle for 12 months. Women will be asked to have liver function tests performed every month through the duration of study participation (12 months). They will be asked to complete a questionnaire/blood loss diary at 3, 6 and 12 months. After 12 months, women will receive an ultrasound, have a blood sample and endometrial biopsy.

WHERE is the study taking place? Multicentre trial (Edinburgh, Glasgow, Aberdeen, Birmingham, Liverpool)

WHO can take part? Women with heavy menstrual bleeding.  Women should be >18yrs, willing to receive treatment with either UPA or LNG-IUS, be willing to undergo two ultrasounds, if randomised to UPA be willing to undergo up to 4 endometrial biopsies, be willing to use barrier contraception and give informed consent. Women who are post-menopausal, pregnant (or planning pregnancy in the next 12 months), breast-feeding or have epilepsy/liver problems/endometrial cancer/significant renal impairment/severe asthma/cancer cannot take part.

Contact details

Research Office: 0131 242 2483 (voicemail available)

Research Mobile: 07871  766031 (text service available)

PEtAL Study

(Phenotyping the Endometrium in Adenomyosis and Leiomyoma): Understanding Local Mechanisms Involved in Uterine Bleeding and Endometrial Function

WHY is it being done? This study aims to understand the changes that are occurring in the womb at a cellular and molecular level, when women have heavy periods which are caused by fibroids (excess growth of the muscle layer of the womb) or adenomyosis (cells from the lining of the womb are found in the muscle layer of the womb).

WHAT is involved? Women attending the gynaecology services, for investigation or treatment of their heavy periods, may need a sampling of the lining of their womb (endometrial biopsy). For this study, we are asking if we can use any surplus tissue which is collected during this sampling. Tissue can also be collected when women are having an operation, such as hysterectomy (removal of the womb).

WHERE is the study taking place? NHS Lothian

WHO can take part?

  • Women with regular menstrual cycles
  • Women not taking hormonal medication
  • Women with fibroids, adenomyosis or both
  • Women with no found cause of their heavy periods

Contact details

Research Office: 0131 242 2483 (voicemail available)

Research Mobile: 07871  766031 (text service available)

Dressed for School is a European project developed in partnership with the French National Museum of Education and Heriot Watt University (communicated in an exhibition and publication in September 2021).

WHY is it being done? This interdisciplinary research questions the interactions between children and their clothes in the School environment from the 19th century onwards, in Western societies. As part of this research, the current question of gender construction and social inequalities in countries where the School uniform is the norm, such as Scotland and the UK, will be addressed. This will include a particular insight into the way the first menstruations may affect the feelings and comfort of young Scottish girls, sometimes in their final years of primary school, surrounded with younger children and lacking adapted spaces and gender privacy. The reaction of the institution and of children, will be analysed via the potential adaptation of the school uniforms to this morphologic and social change.

WHAT is involved? Researchers would like to organise a series of focus groups to discuss these topics.

WHO can take part? Anyone with experience working with pre-teens (e.g. teachers, children, health and well-being officers) who are interested in this topic should contact the team to discuss running a focus group.

Contact details

A.Le_Guennec@hw.ac.uk