The research at EXPPECT Edinburgh is led by Dr Erin Greaves, Professor Andrew Horne, and Professor Philippa Saunders.
Each group focuses on furthering understanding of the causes of chronic pelvic pain, endometriosis symptoms and the development of novel treatment strategies.
Find out more about their research below.
Why endometriosis causes pain is poorly understood but I believe that it is due to the growth of new nerve fibres into endometriosis lesions and their activation by molecules involved in inflammation. Immune cells known as macrophages are attracted to lesions and they are thought to play an important role in encouraging blood vessel and nerve fibre growth into the lesion. My research focuses on how macrophages aid nerve fibre growth and activation in the lesions.
View Dr Erin Greaves' web page for more information.
- Jackie Young (University PA) Email: Jackie.Young@ed.ac.uk Tel: +44 (0) 131 242 6988
- Fiona Elliot (NHS secretary) Email: email@example.com Tel: +44 (0) 131 242 2525
- Please contact Fiona Elliot regarding any personal clinical matters. Tel: +44 (0) 131 242 2525
- Email: Andrew.Horne@ed.ac.uk
- Andrew Horne Twitter feed
Chronic pelvic pain affects over 1 million UK women. Up to 50% will have underlying endometriosis but in the remainder no obvious cause is often identified. We have started a UK-wide multicentre trial to determine whether gabapentin, a drug commonly used to treat other chronic pain conditions, could be an effective treatment for chronic pelvic pain specifically. We have also shown that the cells lining the pelvis are different in women with endometriosis, leading to an altered environment in the pelvis. Our ongoing work aims to use targeted therapies to re-establish a normal healthy pelvic environment and relieve endometriosis symptoms.
View Professor Andrew Horne's web page for more information.
My work with patient groups has identified that women with endometriosis want more effective medical treatments so that they can avoid repeated invasive surgeries and the unwanted side effects associated with current therapies. I believe that novel therapeutics targeting androgen receptors hold significant promise as a medical treatment for the symptoms associated with endometriosis. My team are working towards understanding the androgen-regulated processes relevant to the establishment, and maintenance of, endometriosis lesions and their interaction with pain pathways.
View Professor Philippa Saunders' web page for more information.