MRC Centre for Reproductive Health
MRC Logo JAN 2019

Dr Chih-Jen (Lance) Lin

Research interests, biography and patents.

Dr Chih-Jen (Lance) Lin

Principal Investigator

  • Senior Research Fellow
  • Royal Society of Edinburgh Personal Research Fellow funded by the Scottish Government

Contact details

Address

Street

The Queen’s Medical Research Institute
Edinburgh BioQuarter
47 Little France Crescent

City
Edinburgh
Post Code
EH16 4TJ

Research Interests

Life begins at fertilization. A successful fertilization event occurs when a sperm cell fuses with a healthy oocyte to form a totipotent zygote and initiates embryogenesis. Genetic and epigenetic abnormalities involve during developmental processes lead to failure or defect of birth. Approximately one in seven couples, ~3.5 million people in the UK, have difficulty conceiving (defined as infertility). Dr. Chih-Jen Lin’s research focuses on female infertility specifically in the oocyte health, fertilization and early embryogenesis.

Dr. Lin’s previous studies have demonstrated that epigenetic regulators such as histone variant H3.3 and transcription of ribosomal RNAs have pivotal roles on fertilization (Figure A) and pre-implantation embryonic development (Figure B) in mouse models.

Histone variant H3.3 and transcription of ribosomal RNAs have pivotal roles on fertilization
Figure A
Pre-implantation embryonic development in mouse models.
Figure B

 

Dr. Lin’ long term research goals are to understand the epigenetic reprogramming that occurs during the oocyte-to-zygote transition, pre-implantation stages and the establishment of totipotency/pluripotency.

Current research is focus on:

  1. The role of histone variants and histone chaperones during chromatin/epigenetic reprogramming.
  2. Transcriptional and epigenetic regulation of RNA Pol I, ribosomal RNA biosynthesis and translation in early embryogenesis.
  3. Explore/revisit the processes of oogenesis to understand how the oocyte gains the reprogramming ability to totipotent/pluripotent status and developmental competence.

Biography

Chih-Jen (Lance) Lin received his BS and MS degree from National Taiwan University in Taiwan from prestigious embryologist Prof. Winston Teng-Kuei Cheng’s Lab (renowned as the world’s first scientist to produce test-tube pigs and sheep) working on animal transgenesis. He obtained his PhD degree from University of Connecticut, USA under the supervision of Animal Cloning experts: Prof. Jerry (Xiangzhong) Yang and Cindy (Xiuchun) Tian. He received his solid postdoctoral training of stem cell biology/epigenetics (Dr. Miguel Ramalho-Santos Lab) and oocyte biology (Prof. Marco Conti Lab) in University of California San Francisco, USA. He then conducted a short second postdoctoral training in Prof. Philippe Soriano’s Lab in Icahn School of Medicine at Mount Sinai, New York, USA.

In 2015, He was recruited to the MRC Centre for Reproductive Health at the University of Edinburgh as a Senior Research Fellow to establish his own research group.

Group Members

  • Ms Rowena Smith
  • Dr. Rupsha Fraser

Patents

  1. Cheng, WTK, CM Chen, SW Lin, CH Wang, CJ Lin, and SC Wu. 2004. Transgenic mammal secreting B-domain deleted human FVIII in its milk (USA Patent No. US 7,667,089 B2)
  2. Cheng, WTK, CM Chen, SH Lin, CH Wang, CJ Lin, and SC Wu. 2007. Transgenic animals producing biologically active human factor VIII in their milk driven by mammary-specific expression cassette with intact or B domain-deleted recombinant hFVIII gene constructs. (ROC Patent, Oct 01, 2007~Feb 05, 2024; Patent number: ROC I-287,578.)
  3. Lee, KH, HW Hang, HR Chang, CF Tu, and CJ Lin. 2004. A Method for generating non-human mammalian chimeric embryo. (ROC accepted on Mar 21th, 2010 (092136457) and USA Patents Pended, Pending No.10/875,225.)
  4. Lee, KH, HW Hang, HR Chang, CF Tu, and CJ Lin. 2005. A Method for generating non-human mammalian chimeric embryo. (China Patent CN200410000197.5.)
  5. Cheng WTK, SC Wu, CC Hsu, YS Lin, and CJ Lin. 2011. Novel porcine pancreatic amylase gene promoter and transgenic pigs expressing heterologous digestive enzymes. (USA Patent No. 7,956,238 B2)
  6. Cheng WTK, SC Wu, CC Hsu, YS Lin, and CJ Lin. 2011. Novel porcine pancreatic amylase gene promoter and transgenic pigs expressing heterologous digestive enzymes. (ROC Patent, Oct 21, 2011~May 16, 2026; Patent number: TW095117405)

Technology transfer

Cheng, WTK, SC Wu, and CJ Lin. 2005. Transgenic animal system for mammary-gland-specific expression platform (To the TaiMont Biotechnology Ltd., Jan. 2005 ~ Jan. 2010).